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Antonia Castilho
Researcher at Li Ka Shing Faculty of Medicine, University of Hong Kong
Publications - 6
Citations - 1410
Antonia Castilho is an academic researcher from Li Ka Shing Faculty of Medicine, University of Hong Kong. The author has contributed to research in topics: Liver tumor & Tumor initiation. The author has an hindex of 6, co-authored 6 publications receiving 1316 citations. Previous affiliations of Antonia Castilho include University of Hong Kong.
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Journal ArticleDOI
CD24+ Liver Tumor-Initiating Cells Drive Self-Renewal and Tumor Initiation through STAT3-Mediated NANOG Regulation
Terence Kin Wah Lee,Terence Kin Wah Lee,Antonia Castilho,Antonia Castilho,Vincent Chi Ho Cheung,Vincent Chi Ho Cheung,Kwan Ho Tang,Stephanie Ma,Stephanie Ma,Irene Oi-Lin Ng,Irene Oi-Lin Ng +10 more
TL;DR: These findings point to a CD24 cascade in liver T-ICs that may provide an attractive therapeutic target for HCC patients and to a lentiviral-based knockdown approach.
Journal ArticleDOI
miR-130b Promotes CD133+ Liver Tumor-Initiating Cell Growth and Self-Renewal via Tumor Protein 53-Induced Nuclear Protein 1
Stephanie Ma,Kwan Ho Tang,Yuen Piu Chan,Terence K. Lee,Pak Shing Kwan,Antonia Castilho,Irene Ng,Kwan Man,Nathalie Wong,Ka Fai To,Bo-Jian Zheng,Paul B.S. Lai,Chung Mau Lo,Kwok Wah Chan,Xin Yuan Guan +14 more
TL;DR: In this paper, the identification and characterization of tumor-initiating cells (TICs) from hepatocellular carcinoma (HCC) using the marker CD133 was described.
Tumor-Initiating Cell Growth and Self-Renewal via Tumor Protein 53-Induced Nuclear Protein 1
Stephanie Ma,Kwan Ho Tang,Yuen Piu Chan,Terence K. Lee,Pak Shing Kwan,Antonia Castilho,Irene Ng,Kwan Man,Nathalie Wong,Ka Fai To,Bo-Jian Zheng,Chung Mau Lo,Kwok Wah Chan,Xin Yuan Guan,Li Ka +14 more
TL;DR: Functional studies on miR-130b lentiviral-transduced CD133⁻ cells demonstrated superior resistance to chemotherapeutic agents, enhanced tumorigenicity in vivo, and a greater potential for self renewal.
Journal ArticleDOI
Lupeol targets liver tumor-initiating cells through phosphatase and tensin homolog modulation.
Terence Kin Wah Lee,Terence Kin Wah Lee,Antonia Castilho,Antonia Castilho,Vincent Chi Ho Cheung,Vincent Chi Ho Cheung,Kwan Ho Tang,Stephanie Ma,Stephanie Ma,Irene Oi-Lin Ng,Irene Oi-Lin Ng +10 more
TL;DR: The results suggest that lupeol may be an effective dietary phytochemical that targets liver T‐ICs and exerted a synergistic effect without any adverse effects on body weight when combined with chemotherapeutic drugs.
Journal ArticleDOI
Liver cancer stem cells: implications for a new therapeutic target
TL;DR: The origin of liver stem cells and its relation to HCC development are discussed and the current CSC markers in HCC are summarized to discuss their relevance to the treatment of this deadly disease.