Antonio Frasca

TL;DR: Bioprosthetic heart valves (BHVs) largely circumvent the need for long-term anticoagulation compared with mechanical valves but are increasingly susceptible to deterioration and reduced deformation.

TL;DR: In this paper, the authors established two interacting mechanisms (glycation and serum albumin incorporation) that occur in clinical valves and are sufficient to induce hallmarks of structural degeneration as well as functional deterioration.

TL;DR: Glycation and concomitant HSA infiltration occur in clinical BHV and contribute to structural and functional degeneration of leaflet tissue, thus representing novel, interacting mechanisms of BHVs SVD.

TL;DR: In this paper, the authors investigated the role of glycoxidation on endothelial function and AGE-mediated aortic stiffness and showed that RAP can mitigate AGE mediated endothelial hyperpermeability in vitro and impact on ascending aneurysm in vivo.