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Anabela P. Rolo
Researcher at University of Coimbra
Publications - 120
Citations - 9040
Anabela P. Rolo is an academic researcher from University of Coimbra. The author has contributed to research in topics: Mitochondrion & Mitochondrial permeability transition pore. The author has an hindex of 32, co-authored 115 publications receiving 7575 citations. Previous affiliations of Anabela P. Rolo include Spanish National Research Council & Catholic University of Portugal.
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Journal ArticleDOI
SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function
Nathan L. Price,Ana P. Gomes,Alvin J. Y. Ling,Filipe V. Duarte,Alejandro Martin-Montalvo,Brian J. North,Beamon Agarwal,Lan Ye,Giorgio Ramadori,João S. Teodoro,Basil P. Hubbard,Ana T. Varela,James G. Davis,Behzad Varamini,Angela Hafner,Ruin Moaddel,Anabela P. Rolo,Roberto Coppari,Roberto Coppari,Carlos M. Palmeira,Rafael de Cabo,Joseph A. Baur,David A. Sinclair,David A. Sinclair +23 more
TL;DR: Mice treated with a moderate dose of resveratrol showed increased mitochondrial biogenesis and function, AMPK activation, and increased NAD(+) levels in skeletal muscle, whereas SIRT1 knockouts displayed none of these benefits, whereas a mouse overexpressing Sirt1 mimicked these effects.
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Declining NAD + Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging
Ana P. Gomes,Ana P. Gomes,Nathan L. Price,Alvin J. Y. Ling,Javid Moslehi,Magdalene K. Montgomery,Luis A. Rajman,James P. White,João S. Teodoro,Christiane D. Wrann,Basil P. Hubbard,Evi M. Mercken,Carlos M. Palmeira,Rafael de Cabo,Anabela P. Rolo,Nigel Turner,Eric L. Bell,David A. Sinclair,David A. Sinclair +18 more
TL;DR: It is shown that, during aging, there is a specific loss of mitochondrial, but not nuclear, encoded OXPHOS subunits, and an alternate PGC-1α/β-independent pathway of nuclear-mitochondrial communication contributes to the decline in mitochondrial function with age.
Journal ArticleDOI
Diabetes and mitochondrial function: role of hyperglycemia and oxidative stress.
TL;DR: The main goal of this review is to include a fresh consideration of pathways involved in hyperglycemia-induced diabetic complications, and suggest the possibility of regulation of mitochondrial function at a transcriptional level in response to hyper glycemia.
Journal ArticleDOI
Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis.
TL;DR: Stimulation of mitochondrial function may also prevent NASH development, protecting the cell against the increased flux of reduced substrates to the ETC and ROS generation.
Journal ArticleDOI
Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators
Basil P. Hubbard,Ana P. Gomes,Ana P. Gomes,Han Dai,Jun Li,April Case,Thomas Considine,Thomas V. Riera,Jessica E. Lee,Sook Yen E,Dudley W. Lamming,Bradley L. Pentelute,Eli Schuman,Linda A. Stevens,Alvin J. Y. Ling,Sean M. Armour,Shaday Michan,Huizhen Zhao,Yong Jiang,Sharon Sweitzer,Charles A. Blum,Jeremy S. Disch,Pui Yee Ng,Konrad T. Howitz,Anabela P. Rolo,Anabela P. Rolo,Yoshitomo Hamuro,Joel Moss,Robert B. Perni,James L. Ellis,George P. Vlasuk,David A. Sinclair,David A. Sinclair +32 more
TL;DR: SIRT1 can be directly activated through an allosteric mechanism common to chemically diverse STACs, and specific hydrophobic motifs found in SIRT1 substrates such as PGC-1α and FOXO3a facilitate Sirtuin-activating compounds (STACs) activation by STacs.