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Ignacio Rodríguez-Crespo
Researcher at Complutense University of Madrid
Publications - 67
Citations - 4513
Ignacio Rodríguez-Crespo is an academic researcher from Complutense University of Madrid. The author has contributed to research in topics: Nitric oxide synthase & Palmitoylation. The author has an hindex of 28, co-authored 66 publications receiving 4248 citations. Previous affiliations of Ignacio Rodríguez-Crespo include University of California, San Francisco.
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Journal ArticleDOI
AMP-activated protein kinase phosphorylation of endothelial NO synthase
Zhi-Ping Chen,Ken I. Mitchelhill,Belinda J. Michell,David Stapleton,Ignacio Rodríguez-Crespo,Lee A. Witters,David A. Power,Paul R. Ortiz de Montellano,Bruce E. Kemp +8 more
TL;DR: It is shown that AMPK co‐immunoprecipitates with cardiac endothelial NO synthase (eNOS) and phosphorylates Ser‐1177 in the presence of Ca2+‐calmodulin (CaM) to activate eNOS both in vitro and during ischaemia in rat hearts.
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The Akt kinase signals directly to endothelial nitric oxide synthase.
Belinda J. Michell,J.E. Griffiths,Ken I. Mitchelhill,Ignacio Rodríguez-Crespo,Tony Tiganis,Steven Bozinovski,P R Ortiz de Montellano,Bruce E. Kemp,Richard B. Pearson +8 more
TL;DR: The results strongly suggest that Akt has an important role in the regulation of normal angiogenesis and raise the possibility that the enhanced activity of this kinase that occurs in carcinomas may contribute to tumor vascularization and survival.
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Endothelial nitric-oxide synthase : expression in escherichia coli, spectroscopic characterization, and role of tetrahydrobiopterin in dimer formation
TL;DR: In this paper, BH4-free Bovine endothelial nitricoxide synthase (eNOS) expressed in Escherichia coli does not have the post-translational modifications found in the native enzyme and is free of tetrahydrobiopterin (BH4).
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Protein palmitoylation and subcellular trafficking
TL;DR: An overview of how protein palmitoylation regulates protein trafficking and subcellular localization is given.
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S-nitrosylation of Hsp90 promotes the inhibition of its ATPase and endothelial nitric oxide synthase regulatory activities.
Antonio Martínez-Ruiz,Laura Villanueva,Cecilia González de Orduña,Daniel Lopez-Ferrer,María Ángeles Higueras,Carlos Tarin,Ignacio Rodríguez-Crespo,Jesús Vázquez,Santiago Lamas +8 more
TL;DR: It is suggested that S-nitrosylation may functionally regulate the general activities of Hsp90 and provide a feedback mechanism for limiting eNOS activation.