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Anudeep Yekula
Researcher at Harvard University
Publications - 26
Citations - 369
Anudeep Yekula is an academic researcher from Harvard University. The author has contributed to research in topics: Liquid biopsy & Medicine. The author has an hindex of 7, co-authored 21 publications receiving 159 citations. Previous affiliations of Anudeep Yekula include Guntur Institute of Medical Sciences.
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Journal ArticleDOI
Extracellular Vesicles in Glioblastoma Tumor Microenvironment.
Anuroop Yekula,Anudeep Yekula,Koushik Muralidharan,Keiko Kang,Keiko Kang,Bob S. Carter,Leonora Balaj +6 more
TL;DR: Recent literature in the context of GBM TME is reviewed and the means by which EVs modulate tumor proliferation, reprogram metabolic activity, induce angiogenesis, escape immune surveillance, acquire drug resistance and undergo invasion are reviewed.
Journal ArticleDOI
Large and small extracellular vesicles released by glioma cells in vitro and in vivo
Anudeep Yekula,Valentina R. Minciacchi,Matteo Morello,Huilin Shao,Yongil Park,Xuan Zhang,Koushik Muralidharan,Michael R. Freeman,Ralph Weissleder,Hakho Lee,Bob S. Carter,Xandra O. Breakefield,Dolores Di Vizio,Leonora Balaj +13 more
TL;DR: Both large and small EVs contain tumour-specific EGFRvIII mRNA and proteins and combining these platforms may be beneficial in detecting rare mutant events in circulating biofluids.
Journal ArticleDOI
From laboratory to clinic: Translation of extracellular vesicle based cancer biomarkers.
Anudeep Yekula,Koushik Muralidharan,Keiko M. Kang,Keiko M. Kang,Lan Wang,Leonora Balaj,Bob S. Carter +6 more
TL;DR: The hurdles and potential solutions in EV biomarker discovery and verification and validation, and clinical translation are discussed.
Journal ArticleDOI
TERT Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas.
Koushik Muralidharan,Anudeep Yekula,Julia L. Small,Zachary S. Rosh,Keiko M. Kang,Keiko M. Kang,Lan Wang,Spencer Lau,Hui Zhang,Hakho Lee,Chetan Bettegowda,Michael R. Chicoine,Steven N. Kalkanis,Ganesh M. Shankar,Brian V. Nahed,William T. Curry,Pamela S. Jones,Daniel P. Cahill,Leonora Balaj,Bob S. Carter +19 more
TL;DR: A novel digital droplet PCR assay that incorporates features to improve sensitivity and allows for the simultaneous detection and longitudinal monitoring of two TERT promoter mutations in cfDNA from the plasma of patients with glioma is developed.
Journal ArticleDOI
Navigating the Landscape of Tumor Extracellular Vesicle Heterogeneity
Sabrina Roy,Hsing Ying Lin,Chung Yu Chou,Chung Yu Chou,Chen Han Huang,Julia L. Small,Noah Sadik,Noah Sadik,Caroline M. Ayinon,Elizabeth Lansbury,Lilian Cruz,Anudeep Yekula,Pamela S. Jones,Leonora Balaj,Bob S. Carter +14 more
TL;DR: An overview of currently available and potentially applicable methods for single EV analysis is provided and the latest findings from experiments that have analyzed the issue at the single EV level are examined to discuss potential implications.