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Aras Kadioglu
Researcher at University of Liverpool
Publications - 129
Citations - 8235
Aras Kadioglu is an academic researcher from University of Liverpool. The author has contributed to research in topics: Streptococcus pneumoniae & Pneumolysin. The author has an hindex of 44, co-authored 118 publications receiving 7200 citations. Previous affiliations of Aras Kadioglu include University Hospitals of Leicester NHS Trust & University of Leicester.
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Journal ArticleDOI
The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease.
TL;DR: This Review describes how S. pneumoniae uses its armamentarium of virulence factors to colonize the upper and lower respiratory tracts of the host and cause disease.
Journal ArticleDOI
Alternatives to antibiotics—a pipeline portfolio review
Lloyd George Czaplewski,Richard Bax,Martha R. J. Clokie,Michael J. Dawson,Heather Fairhead,Vincent A. Fischetti,Simon J. Foster,Brendan Gilmore,Robert E. W. Hancock,David R Harper,Ian R. Henderson,Kai Hilpert,Brian V. Jones,Brian V. Jones,Aras Kadioglu,David Knowles,Sigríður Ólafsdóttir,David J. Payne,Steve Projan,Sunil Shaunak,Jared Silverman,Christopher M. Thomas,Trevor J. Trust,Peter Warn,John H. Rex +24 more
TL;DR: This first wave of alternatives to antibiotics will probably best serve as adjunctive or preventive therapies, which suggests that conventional antibiotics are still needed.
Journal ArticleDOI
Pneumolysin Activates the NLRP3 Inflammasome and Promotes Proinflammatory Cytokines Independently of TLR4
Edel A. McNeela,Aine Burke,Daniel R. Neill,Cathy Baxter,Vitor E. Fernandes,Daniela M. Ferreira,Sarah Smeaton,Rana G. El-Rachkidy,Rachel M. McLoughlin,Andres Mori,Barry Moran,Katherine A. Fitzgerald,Jürg Tschopp,Virginie Pétrilli,Peter W. Andrew,Aras Kadioglu,Ed C. Lavelle +16 more
TL;DR: In this paper, the effects of pneumolysin on Dendritic cells (DC) were investigated and it was shown that PLY-induced DC maturation and cytokine secretion by DC and splenocytes was TLR4-independent.
Journal ArticleDOI
Switch from planktonic to sessile life: a major event in pneumococcal pathogenesis.
Marco R. Oggioni,Claudia Trappetti,Aras Kadioglu,Marco Cassone,Francesco Iannelli,Susanna Ricci,Peter W. Andrew,Gianni Pozzi +7 more
TL;DR: The data enable us, using in vivo gene expression and in vivo modulation of virulence, to postulate the distinction – from the pneumococcal point of view – between two main types of disease.
Journal ArticleDOI
The role of pneumolysin in pneumococcal pneumonia and meningitis
TL;DR: Extensive studies on the role of pneumolysin in the pathogenesis of pneumococcal diseases are reviewed, finding that it is a common precursor of meningitis and septicaemia.