A
Arda Shahinian
Researcher at Ontario Institute for Cancer Research
Publications - 42
Citations - 14909
Arda Shahinian is an academic researcher from Ontario Institute for Cancer Research. The author has contributed to research in topics: T cell & CD28. The author has an hindex of 31, co-authored 42 publications receiving 14465 citations. Previous affiliations of Arda Shahinian include University Health Network & Discovery Institute.
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Journal ArticleDOI
Lymphoproliferative Disorders with Early Lethality in Mice Deficient in Ctla-4
Paul Waterhouse,Josef M. Penninger,Emma Timms,Andrew Wakeham,Arda Shahinian,Kelvin P. Lee,Craig B. Thompson,Henrik Griesser,Tak W. Mak +8 more
TL;DR: Although CTLA-4-deficient T cells proliferated spontaneously and strongly when stimulated through the T cell receptor, they were sensitive to cell death induced by cross-linking of the Fas receptor and by gamma irradiation, and is vital for the control of lymphocyte homeostasis.
Journal ArticleDOI
Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection.
Klaus Pfeffer,Toshifumi Matsuyama,Thomas M. Kündig,Andrew Wakeham,Kenji Kishihara,Arda Shahinian,Katja Wiegmann,Pamela S. Ohashi,Martin Krönke,Tak W. Mak +9 more
TL;DR: The TNFRp55 function renders mice resistant to lethal dosages of either lipopolysaccharides or S. aureus enterotoxin B, and the 55 kd TNFR plays a decisive role in the host's defense against microorganisms and their pathogenic factors.
Journal ArticleDOI
Differential T cell costimulatory requirements in CD28-deficient mice
Arda Shahinian,Klaus Pfeffer,Kelvin P. Lee,Thomas M. Kündig,Kenji Kishihara,Andrew Wakeham,Kazuhiro Kawai,Pamela S. Ohashi,Craig B. Thompson,Tak W. Mak +9 more
TL;DR: CD28 is not required for all T cell responses in vivo, suggesting that alternative costimulatory pathways may exist.
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FADD: Essential for Embryo Development and Signaling from Some, But Not All, Inducers of Apoptosis
Wen-Chen Yeh,José Luis de la Pompa,Mila E. McCurrach,Hong-Bing Shu,Andrew J. Elia,Arda Shahinian,Michelle Ng,Andrew Wakeham,Wilson Khoo,Kyran O. Mitchell,Wafik S. El-Deiry,Scott W. Lowe,David V. Goeddel,Tak W. Mak +13 more
TL;DR: CD95, tumor necrosis factor receptor type 1 (TNFR-1), and death receptor 3 (DR3) did not induce apoptosis in FADD-deficient embryonic fibroblasts, whereas DR4, oncogenes E1A and c-myc, and chemotherapeutic agent adriamycin did.
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Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes
Minna Woo,Razqallah Hakem,Maria S. Soengas,Gordon S. Duncan,Arda Shahinian,David Kägi,Anne Hakem,Mila E. McCurrach,Wilson Khoo,Stephen Kaufman,Giorgio Senaldi,Tamara Howard,Scott W. Lowe,Tak W. Mak +13 more
TL;DR: Examination of the role of CPP32 in apoptosis using mice, embryonic stem cells, and mouse embryonic fibroblasts deficient for the caspase indicates that CPP 32 is an essential component in apoptotic events that is remarkably system- and stimulus-dependent.