B
Barry S. Komm
Researcher at Pfizer
Publications - 154
Citations - 12096
Barry S. Komm is an academic researcher from Pfizer. The author has contributed to research in topics: Selective estrogen receptor modulator & Bazedoxifene. The author has an hindex of 51, co-authored 152 publications receiving 11487 citations. Previous affiliations of Barry S. Komm include University of Arizona.
Papers
More filters
Journal ArticleDOI
Canonical WNT Signaling Promotes Osteogenesis by Directly Stimulating Runx2 Gene Expression
Tripti Gaur,Christopher J. Lengner,Hayk Hovhannisyan,Ramesh A. Bhat,Peter V.N. Bodine,Barry S. Komm,Amjad Javed,Andre J. van Wijnen,Janet L. Stein,Gary S. Stein,Jane B. Lian +10 more
TL;DR: It is proposed that WNT/TCF1 signaling, like bone morphogenetic protein/transforming growth factor-β signaling, activates Runx2 gene expression in mesenchymal cells for the control of osteoblast differentiation and skeletal development.
Journal ArticleDOI
Profiling of estrogen up- and down-regulated gene expression in human breast cancer cells: insights into gene networks and pathways underlying estrogenic control of proliferation and cell phenotype.
Jonna Frasor,Jeanne M. Danes,Barry S. Komm,Ken C. N. Chang,C. Richard Lyttle,Benita S. Katzenellenbogen +5 more
TL;DR: The use of global gene expression profiling by Affymetrix GeneChip microarray analysis to identify patterns and time courses of genes that are either stimulated or inhibited by estradiol (E2) in estrogen receptor (ER)-positive MCF-7 human breast cancer cells is highlighted.
Journal ArticleDOI
Estrogen binding, receptor mRNA, and biologic response in osteoblast-like osteosarcoma cells
Barry S. Komm,Christopher M. Terpening,David J. Benz,Kimberlie A. Graeme,Alfred Gallegos,Murray Korc,Geoffrey L. Greene,Bert W. O'Malley,Mark R. Haussler +8 more
TL;DR: Estradiol can act directly on osteoblasts by a receptor-mediated mechanism and thereby modulate the extracellular matrix and other proteins involved in the maintenance of skeletal mineralization and remodeling.
Journal ArticleDOI
Selective estrogen receptor modulators: discrimination of agonistic versus antagonistic activities by gene expression profiling in breast cancer cells.
Jonna Frasor,Fabio Stossi,Jeanne M. Danes,Barry S. Komm,C. Richard Lyttle,Benita S. Katzenellenbogen +5 more
TL;DR: In this paper, the effects of tamoxifen and raloxifene on the expression of approximately 12,000 genes, using Affymetrix GeneChip microarrays, with quantitative PCR verification in many cases.
Journal ArticleDOI
Wnt/β-Catenin Signaling Is a Normal Physiological Response to Mechanical Loading in Bone
John A. Robinson,Moitreyee Chatterjee-Kishore,Paul J. Yaworsky,Diane M. Cullen,Weiguang Zhao,Christine Li,Yogendra P. Kharode,Linda Sauter,Philip Babij,Eugene L. Brown,Andrew A. Hill,Mohammed P. Akhter,Mark L. Johnson,Robert R. Recker,Barry S. Komm,Frederick J. Bex +15 more
TL;DR: In vivo and in vitro mechanical loading results support that Wnt/β-catenin signaling is a normal physiological response to load and that activation of the Wnt /β- catenin pathway enhances the sensitivity of osteoblasts/osteocytes to mechanical loading.