M
Marisa S. Bartolomei
Researcher at University of Pennsylvania
Publications - 199
Citations - 21699
Marisa S. Bartolomei is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Genomic imprinting & DNA methylation. The author has an hindex of 67, co-authored 189 publications receiving 19804 citations. Previous affiliations of Marisa S. Bartolomei include Uniformed Services University of the Health Sciences & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ)
Han Cho,James Mu,Jason K. Kim,Jason K. Kim,Joanne L. Thorvaldsen,Qingwei Chu,E. Bryan Crenshaw,Klaus H. Kaestner,Marisa S. Bartolomei,Gerald I. Shulman,Gerald I. Shulman,Morris J. Birnbaum +11 more
TL;DR: It is shown that mice deficient in Akt2 are impaired in the ability of insulin to lower blood glucose because of defects in the action of the hormone on liver and skeletal muscle, establishing Akt 2 as an essential gene in the maintenance of normal glucose homeostasis.
Journal ArticleDOI
Parental imprinting of the mouse H19 gene.
TL;DR: An RNase protection assay is used that can distinguish between H19 alleles in four subspecies of Mus, to demonstrate that the H19 gene is parentally imprinted, with the active copy derived from the mother.
Journal ArticleDOI
Genomic imprinting in mammals.
TL;DR: Although the function of imprinting remains a subject of some debate, the process is thought to have an important role in regulating the rate of fetal growth.
Journal ArticleDOI
Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair.
Salvatore Cortellino,Jinfei Xu,Mara Sannai,Robert Moore,Elena Caretti,Antonio Cigliano,Madeleine Le Coz,Karthik Devarajan,Andy Wessels,Dianne Robert Soprano,Lara K. Abramowitz,Marisa S. Bartolomei,Florian Rambow,Florian Rambow,Maria Rosaria Bassi,Tiziana Bruno,Maurizio Fanciulli,Catherine Renner,Andres J. Klein-Szanto,Yoshihiro Matsumoto,Dominique Kobi,Irwin Davidson,Christophe Alberti,Christophe Alberti,Lionel Larue,Lionel Larue,Alfonso Bellacosa +26 more
TL;DR: It is shown that either knockout or catalytic inactivation of the DNA repair enzyme thymine DNA glycosylase (TDG) leads to embryonic lethality in mice, and a dual role for TDG in promoting proper epigenetic states during development is highlighted, suggesting a two-step mechanism for DNA demethylation in mammals.
Journal ArticleDOI
Differential Effects of Culture on Imprinted H19 Expression in the Preimplantation Mouse Embryo
Adam S. Doherty,Adam S. Doherty,Mellissa R.W. Mann,Kimberly D. Tremblay,Marisa S. Bartolomei,Richard M. Schultz +5 more
TL;DR: The finding that culture conditions can dramatically, but selectively, affect the expression of imprinted genes provides a model system for further study of the linkage between DNA methylation and gene expression.