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Armiyaw S. Nasamu
Researcher at Washington University in St. Louis
Publications - 19
Citations - 1687
Armiyaw S. Nasamu is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Plasmodium falciparum & Genome. The author has an hindex of 10, co-authored 16 publications receiving 1186 citations. Previous affiliations of Armiyaw S. Nasamu include Massachusetts Institute of Technology.
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A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes.
Saima M. Sidik,Diego Huet,Suresh M. Ganesan,My Hang Huynh,Timothy C. Wang,Timothy C. Wang,Armiyaw S. Nasamu,Prathapan Thiru,Jeroen P. J. Saeij,Vern B. Carruthers,Jacquin C. Niles,Sebastian Lourido +11 more
TL;DR: In this article, the authors adapted CRISPR/Cas9 to assess the contribution of each gene from the parasite Toxoplasma gondii during infection of human fibroblasts.
A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes
Saima M. Sidik,Diego Huet,My Hang Huynh,Prathapan Thiru,Jeroen P. J. Saeij,Vern B. Carruthers,Sebastian Lourido,Suresh M. Ganesan,Armiyaw S. Nasamu,Jacquin C. Niles,Timothy C. Wang +10 more
TL;DR: The first genome-wide genetic screen of an apicomplexan parasite is presented, revealing essential functions during infection of human cells and providing broad-based functional information on T. gondii genes that will facilitate future approaches to expand the horizon of antiparasitic interventions.
Journal ArticleDOI
Synthetic RNA–protein modules integrated with native translation mechanisms to control gene expression in malaria parasites
TL;DR: A broadly applicable strategy for robustly controlling protein translation by integrating synthetic translational control via a small-molecule-regulated RNA–protein module with native mechanisms that simultaneously regulate multiple facets of cellular RNA fate is introduced.
Journal ArticleDOI
Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion
Armiyaw S. Nasamu,Svetlana Glushakova,Ilaria Russo,Barbara A. Vaupel,Anna Oksman,Arthur S. Kim,Daved H. Fremont,Niraj H. Tolia,Josh R. Beck,Marvin J. Meyers,Jacquin C. Niles,Joshua Zimmerberg,Daniel E. Goldberg +12 more
TL;DR: It is shown that PMIX is essential for erythrocyte invasion, acting on rhoptry secretory organelle biogenesis, and PMX isessential for both egress and invasion, controlling maturation of the subtilisin-like serine protease SUB1 in exoneme secretory vesicles.
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Muscle-specific SIRT1 gain-of-function increases slow-twitch fibers and ameliorates pathophysiology in a mouse model of duchenne muscular dystrophy.
TL;DR: In this article, SIRT1 overexpression in muscle transgenic mice was shown to reverse the phenotype of Duchenne muscular dystrophy, as determined by histology, creatine kinase release into the blood, and endurance in treadmill exercise.