Arnab Datta

TL;DR: In this article, the authors observed that tumor cells produce a secretion that modifies their microenvironment to facilitate tumor angiogenesis and metastasis under hypoxia, and the secreted proteins were predominantly cytoplasmic and membrane proteins.

TL;DR: An optimized protocol using electrostatic repulsion hydrophilic interaction chromatography for the simultaneous enrichment of glyco- and phosphopeptides from mouse brain membrane protein digest is reported here to study the complex interaction of two different post-translational modifications in health and disease without being affected by interexperimental variations.

TL;DR: These findings suggest that the association of SF3B1 with nucleosomes is functionally important for splice-site recognition and that SF3 B1 conveys splicing-relevant information embedded in chromatin structure.

TL;DR: This study shows the potential application of iTRAQ-based quantitative proteomics for the elucidation of pathophysiology and the discovery of novel therapeutic targets in the field of neuroproteomics.

TL;DR: The data showed the voltage gating of porin OmpF in vivo for the first time and supported the proposed mechanism that the local electrostatic field changes in the eyelet region may alter the porin channels to switch.