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Arnaud Guille
Researcher at Aix-Marseille University
Publications - 53
Citations - 1074
Arnaud Guille is an academic researcher from Aix-Marseille University. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 15, co-authored 39 publications receiving 789 citations. Previous affiliations of Arnaud Guille include French Institute of Health and Medical Research.
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Journal ArticleDOI
Down-Regulation of ECRG4, a Candidate Tumor Suppressor Gene, in Human Breast Cancer
Renaud Sabatier,Pascal Finetti,José Adélaïde,Arnaud Guille,Jean-Paul Borg,Max Chaffanet,Lydie Lane,Daniel Birnbaum,François Bertucci +8 more
TL;DR: The data suggest that ECRG4 is a candidate TSG in breast cancer, the expression of which may help improve the prognostication, if functional analyses confirm this TSG role.
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Mevalonate Metabolism Regulates Basal Breast Cancer Stem Cells and Is a Potential Therapeutic Target
Christophe Ginestier,Florence Monville,Julien Wicinski,Olivier Cabaud,Nathalie Cervera,Emmanuelle Josselin,Pascal Finetti,Arnaud Guille,Gaelle Larderet,Patrice Viens,Said M. Sebti,François Bertucci,François Bertucci,Daniel Birnbaum,Emmanuelle Charafe-Jauffret,Emmanuelle Charafe-Jauffret +15 more
TL;DR: Modulation of this metabolic pathway demonstrated that protein geranylgeranylation (GG) is critical to breast CSC maintenance, and opens promising perspectives for CSC targeted therapy in basal breast cancer.
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Claudin-low breast cancers: clinical, pathological, molecular and prognostic characterization
Renaud Sabatier,Renaud Sabatier,Pascal Finetti,Arnaud Guille,José Adélaïde,Max Chaffanet,Patrice Viens,Daniel Birnbaum,François Bertucci +8 more
TL;DR: A comprehensive characterization of the largest series of claudin-low (CL) subtype of breast cancer samples reported so far is provided, suggesting a larger heterogeneity than in basal and luminal A subtypes.
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Comparative genomic analysis of primary tumors and metastases in breast cancer.
François Bertucci,Pascal Finetti,Arnaud Guille,José Adélaïde,Séverine Garnier,Nadine Carbuccia,Audrey Monneur,Emmanuelle Charafe-Jauffret,Anthony Gonçalves,Patrice Viens,Daniel Birnbaum,Max Chaffanet +11 more
TL;DR: The results suggest that the genotyping of primary tumor may be acceptable to guide systemic treatment if the metastatic sample is not obtainable, however, given the rare but potentially relevant divergences for some actionable driver genes, the profiling of metastasis sample is recommended.
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Candidate luminal B breast cancer genes identified by genome, gene expression and DNA methylation profiling.
Stéphanie Cornen,Arnaud Guille,José Adélaïde,Lynda Addou-Klouche,Pascal Finetti,Marie-Rose Saade,Marwa Manai,Nadine Carbuccia,Ismahane Bekhouche,Anne Letessier,Stéphane Raynaud,Emmanuelle Charafe-Jauffret,Jocelyne Jacquemier,Salvatore Spicuglia,Patrice Viens,François Bertucci,Daniel Birnbaum,Max Chaffanet +17 more
TL;DR: Luminal B candidate genes that may play a role in the development and/or hormone resistance of this aggressive subtype are reported and KCNB2 mutations were associated with luminal B cases while candidate TSGs MDN1 and UTRN were mutated in this subtype.