J
Julien Wicinski
Researcher at Aix-Marseille University
Publications - 22
Citations - 3206
Julien Wicinski is an academic researcher from Aix-Marseille University. The author has contributed to research in topics: Stem cell & Cancer stem cell. The author has an hindex of 12, co-authored 18 publications receiving 2831 citations. Previous affiliations of Julien Wicinski include French Institute of Health and Medical Research.
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Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature.
Emmanuelle Charafe-Jauffret,Christophe Ginestier,Flora Iovino,Julien Wicinski,Nathalie Cervera,Pascal Finetti,Min-Hee Hur,Mark E. Diebel,Florence Monville,Julie Dutcher,Marthy Brown,Patrice Viens,Luc Xerri,François Bertucci,Giorgio Stassi,Gabriela Dontu,Daniel Birnbaum,Max S. Wicha +17 more
TL;DR: It is shown that ALDEFLUOR-positive cells are responsible for mediating metastasis and the hierarchical organization of immortalized cell lines, establish techniques that can facilitate the characterization of regulatory pathways of CSCs, and identify potential stem cell markers and therapeutic targets.
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CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts
Christophe Ginestier,Suling Liu,Mark E. Diebel,Hasan Korkaya,Ming Luo,Marty Brown,Julien Wicinski,Olivier Cabaud,Emmanuelle Charafe-Jauffret,Daniel Birnbaum,Jun-Lin Guan,Gabriela Dontu,Max S. Wicha +12 more
TL;DR: The development of a strategy to target these breast cancer stem cells (CSCs) through blockade of the IL-8 receptor CXCR1 and repertaxin was able to specifically target the CSC population in human breast cancer xenografts, retarding tumor growth and reducing metastasis.
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Salinomycin kills cancer stem cells by sequestering iron in lysosomes
Trang Thi Mai,Ahmed Hamaï,Antje Hienzsch,Tatiana Cañeque,Sebastian Müller,Sebastian Müller,Sebastian Müller,Julien Wicinski,Olivier Cabaud,Christine Leroy,Amandine David,Verónica Acevedo,Verónica Acevedo,Verónica Acevedo,Akihide Ryo,Christophe Ginestier,Daniel Birnbaum,Emmanuelle Charafe-Jauffret,Patrice Codogno,Maryam Mehrpour,Raphaël Rodriguez +20 more
TL;DR: Evidence is provided that a synthetic derivative of salinomycin, which is named ironomycin (AM5), exhibits a more potent and selective activity against breast CSCs in vitro and in vivo, by accumulating and sequestering iron in lysosomes.
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Retinoid signaling regulates breast cancer stem cell differentiation.
Christophe Ginestier,Julien Wicinski,Nathalie Cervera,Florence Monville,Pascal Finetti,François Bertucci,Max S. Wicha,Daniel Birnbaum,Emmanuelle Charafe-Jauffret +8 more
TL;DR: The role of retinoid signaling is demonstrated in the regulation of breast CSCs self-renewal and differentiation and gene sets and pathways associated with retinoids signaling are identified using the GSEA algorithm.
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The histone deacetylase inhibitor abexinostat induces cancer stem cells differentiation in breast cancer with low Xist expression
Marion A. Salvador,Julien Wicinski,Olivier Cabaud,Yves Toiron,Pascal Finetti,Emmanuelle Josselin,Hélène Lelièvre,Laurence Kraus-Berthier,Stéphane Depil,François Bertucci,Yves Collette,Daniel Birnbaum,Emmanuelle Charafe-Jauffret,Christophe Ginestier +13 more
TL;DR: This study identified the long noncoding RNA Xist (X-inactive specific transcript) as a biomarker predicting BCL response to HDACi and validated that low Xist expression predicts drug response in PDXs associated with a significant reduction of the breast CSC population.