Arno Doelemeyer

TL;DR: It is concluded that inhibition of Notch2 prevents goblet cell metaplasia induced by a broad range of stimuli and proposed notch2 neutralization as a therapeutic strategy for preventing gobleT cell metaPLasia in airway diseases.

TL;DR: The data indicate that the choroid regulates its blood flow better during exercise-induced changes in MAP than during an experimental increase in IOP, and confirms previously published observations that the Choroid shows some autoregulatory capacity during changes in OPP.

TL;DR: It is found that Memo was required for migration and invasion of breast cancer cells in vitro and spontaneous lung metastasis from breast cancer cell xenografts in vivo and was an independent prognostic factor of early distant metastasis.

TL;DR: A rodent model of Achilles tendon injury is used to demonstrate that the composite hydrogels allow for highly extended and localized release of biological drugs in vivo, while demonstrating biodegradation and biocompatibility.

TL;DR: Pharmacological inhibition of RORC not only blocks Th17 cell development and related cytokine production, but also recapitulates thymic aberrations seen in Rorc-deficient mice, which may offer an effective therapeutic principle for Th17-mediated diseases.