Michaela Kneissel

TL;DR: Current understanding of the mechanisms by which WNT signalng regulates bone homeostasis is reviewed, finding the pathway is now the target for therapeutic intervention to restore bone strength in millions of patients at risk for fracture.

TL;DR: It is shown that PTH directly inhibits SOST transcription in vivo and in vitro, suggesting that SOST regulation may play a role in mediating PTH action in bone.

TL;DR: Results reveal a crucial novel function for osteocyte β-catenin signaling in controlling bone homeostasis in osteocyte-specific β- catenin mutants.

TL;DR: It is demonstrated that mice survive well without HDAC6 and that tubulin hyperacetylation is not detrimental to normal mammalian development, and that this deacetylase plays a minor role in bone biology.

TL;DR: A comparative sequence-based approach to characterize a large noncoding region deleted in patients affected by Van Buchem (VB) disease, a severe sclerosing bone dysplasia, and identifies a candidate enhancer element that drives human SOST expression in osteoblast-like cell lines in vitro and in the skeletal anlage of the embryonic day 14.5 mouse embryo.