Haidi Yang

TL;DR: It is shown that cellular uptake of L-glutamine and its subsequent rapid efflux in the presence of essential amino acids (EAA) is the rate-limiting step that activates mTOR.

TL;DR: The studies suggest that IMiDs block endogenous substrates (MEIS2) from binding to CRL4CRBN while the ligase complex is recruiting IKZF1 or IKzF3 for degradation, which implies that small molecules can modulate an E3 ubiquitin ligase and thereby upregulate or downregulate the ubiquitination of proteins.

TL;DR: It is concluded that inhibition of Notch2 prevents goblet cell metaplasia induced by a broad range of stimuli and proposed notch2 neutralization as a therapeutic strategy for preventing gobleT cell metaPLasia in airway diseases.

TL;DR: This work identifies genes modifying endogenous mHTT using high-throughput screening and demonstrates NUB1 as an exemplar entry point for therapeutic intervention of Huntington's disease.

TL;DR: In this paper , a rotated staggered-grid finite-difference (RSG-FD) method with an unsplit convolutional perfectly matched layer (C-PML) absorbing boundary is used to solve a first-order velocity-stress formulation of poro-acoustoelasticity equations for elastic wave propagation in prestressed porous media.