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Arthur A. Vandenbark
Researcher at Oregon Health & Science University
Publications - 134
Citations - 7372
Arthur A. Vandenbark is an academic researcher from Oregon Health & Science University. The author has contributed to research in topics: Experimental autoimmune encephalomyelitis & T cell. The author has an hindex of 41, co-authored 134 publications receiving 6920 citations. Previous affiliations of Arthur A. Vandenbark include Veterans Health Administration & United States Department of Veterans Affairs.
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Journal ArticleDOI
CD4 T-cell epitopes of human α B-crystallin
Yuan K. Chou,Gregory G. Burrows,Dorian LaTocha,Chunhe Wang,Sandhya Subramanian,Dennis Bourdette,Dennis Bourdette,Arthur A. Vandenbark,Arthur A. Vandenbark +8 more
TL;DR: Findings suggest that autoreactive α B‐crystallin‐specific Th1 cells may have the potential to contribute to MS pathogenesis.
Journal ArticleDOI
Rationally designed mutations convert complexes of human recombinant T cell receptor ligands into monomers that retain biological activity.
Jianya Y. Huan,Roberto Meza-Romero,Jeffery L. Mooney,Yuan K. Chou,David M. Edwards,Cathleen Rich,Jason M. Link,Arthur A. Vandenbark,Arthur A. Vandenbark,Dennis Bourdette,Hans Peter Bächinger,Gregory G. Burrows +11 more
TL;DR: These studies demonstrated that RTLs encoding the Ag-binding/TCR recognition domain of MHC class II molecules are innately very robust structures, capable of retaining potent biological activity separate from the Ig-fold domains of the progenitor class II structure, with prevention of aggregation accomplished by modification of an exposed surface that was buried in the progensitor structure.
Journal ArticleDOI
Interleukin 7 is a potent co-stimulator of myelin specific t cells that enhances the adoptive transfer of experimental autoimmune encephalomyelitis
Bruce F. Bebo,Jeanette C Schuster,Kirsten Adlard,Arthur A. Vandenbark,Arthur A. Vandenbark,Halina Offner,Halina Offner +6 more
TL;DR: The results suggest that IL-7 may be a critical co-stimulatory factor that enhances the extrathymic expansion of inflammatory T cells and may play an important role in the pathogenesis of a number of inflammatory autoimmune disorders.
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Activation Pathways Implicate Anti-HLA-DP and Anti-LFA-1 Antibodies as Lead Candidates for Intervention in Chronic Berylliosis
Yuan K. Chou,David M. Edwards,Andrew D. Weinberg,Arthur A. Vandenbark,Arthur A. Vandenbark,Brian L. Kotzin,Andrew P. Fontenot,Gregory G. Burrows +7 more
TL;DR: Results indicate a prominent role for HLA-DP and LFA-1 in BAL CD4+ T cell activation and further suggest that specific Abs to these molecules could serve as a possible therapy for chronic beryllium disease.
Journal ArticleDOI
T lymphocytes promote the development of bone marrow-derived APC in the central nervous system.
Sandhya Subramanian,Dennis Bourdette,Dennis Bourdette,Christopher L. Corless,Arthur A. Vandenbark,Arthur A. Vandenbark,Halina Offner,Richard E. Jones +7 more
TL;DR: It is demonstrated that T cells modulate the development of BM-derived CNS APC in an Ag-independent fashion and may be relevant to pathogenesis in experimental autoimmune encephalomyelitis, multiple sclerosis, and/or other CNS diseases involving myelomonocytic lineage cells.