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Arthur A. Vandenbark
Researcher at Oregon Health & Science University
Publications - 134
Citations - 7372
Arthur A. Vandenbark is an academic researcher from Oregon Health & Science University. The author has contributed to research in topics: Experimental autoimmune encephalomyelitis & T cell. The author has an hindex of 41, co-authored 134 publications receiving 6920 citations. Previous affiliations of Arthur A. Vandenbark include Veterans Health Administration & United States Department of Veterans Affairs.
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Journal ArticleDOI
Middle-Age Male Mice Have Increased Severity of Experimental Autoimmune Encephalomyelitis and Are Unresponsive to Testosterone Therapy
Agata Matejuk,Agata Matejuk,Agata Matejuk,Corwyn Hopke,Arthur A. Vandenbark,Patricia D. Hurn,Halina Offner +6 more
TL;DR: Striking differences between middle-age vs young C57BL/6 male mice in the clinical course of EAE and response to both testosterone (T4) and estrogen (E2) hormone therapy are demonstrated, the first to define age-dependent differences in EAE expression and Response to hormone therapy.
Journal ArticleDOI
Treatment of experimental stroke with IL-10-producing B-cells reduces infarct size and peripheral and CNS inflammation in wild-type B-cell-sufficient mice.
Sheetal Bodhankar,Sheetal Bodhankar,Yingxin Chen,Arthur A. Vandenbark,Arthur A. Vandenbark,Stephanie J. Murphy,Halina Offner +6 more
TL;DR: These studies are the first to demonstrate a major immunoregulatory role for IL-10+ regulatory B-cells in preventing and treating MCAO in WT mice and also implicating their potential role in attenuating complications due to post-stroke immunosuppression.
Journal ArticleDOI
Phenotypic Changes in Immune Cell Subsets Reflect Increased Infarct Volume in Male vs. Female Mice
Anirban Banerjee,Anirban Banerjee,Jianming Wang,Sheetal Bodhankar,Sheetal Bodhankar,Arthur A. Vandenbark,Arthur A. Vandenbark,Stephanie J. Murphy,Halina Offner,Halina Offner +9 more
TL;DR: It is observed that males have a greater percentage of activated macrophages/microglia in the brain than females, as well as increased expression of the VLA-4 adhesion molecule in both brain and spleen, implying that effective treatments for human stroke may also be gender specific.
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T lymphocytes do not directly mediate the protective effect of estrogen on experimental autoimmune encephalomyelitis
Magdalena J. Polanczyk,Richard E. Jones,Richard E. Jones,Sandhya Subramanian,Michael Afentoulis,Cathleen Rich,Melissa A. Zakroczymski,Paul S. Cooke,Arthur A. Vandenbark,Arthur A. Vandenbark,Halina Offner,Halina Offner +11 more
TL;DR: It is shown that estrogen receptor-alpha (Esr1) is crucial for the protective effect of 17 beta-estradiol (E2) in murine experimental autoimmune encephalitis (EAE), an animal model of multiple sclerosis, and the first demonstration that the Protective effect of E2 on EAE is not mediated directly through E2-responsive T cells is provided.
Journal ArticleDOI
Evaluation of the Effects of 17β-Estradiol (17β-E2) on Gene Expression in Experimental Autoimmune Encephalomyelitis Using DNA Microarray
Agata Matejuk,Agata Matejuk,Agata Matejuk,Jami Dwyer,Alex Zamora,Arthur A. Vandenbark,Arthur A. Vandenbark,Halina Offner,Halina Offner +8 more
TL;DR: The results implicate a limited set of known and previously unsuspected E2-sensitive genes that may be crucial for inhibition of EAE and potentially the human disease, multiple sclerosis.