Arthur Felix

TL;DR: This first synthetic peptide parenteral vaccine against a communicable disease tested in man is safe and stimulates biologically active antibodies, which encourage the development of improved vaccine formulations which, by enhancing immunogenicity, may lead to practical vaccines to assist in the control of falciparum malaria.

TL;DR: The self-assembly of the soluble peptide Abeta into Alzheimer's disease amyloid is believed to involve a conformational change and because fibrillization leads to formation of intermolecular beta-sheet secondary structure, a global conformational rearrangement is highly likely.

TL;DR: Conformational analysis (circular dichroism and molecular dynamics calculations based on NOE-derived distance constraints) demonstrated that cyclo8,12[Asp8,Ala15]-GRF(1-29)-NH2 contains a long alpha-helical segment even in aqueous solution.

TL;DR: It is reported here that an active congener, Aβ(10−35)-NH2, displays time dependence, pH−activity profile, and kinetic order of deposition similar to A β(1−40), and is sufficiently soluble for NMR spectroscopy in water under conditions where it actively deposits.

TL;DR: It is demonstrated that no conformations are present in water under conditions where the peptides can adhere to authentic amyloid plaques and a helical conformation is proposed in plaque formation.