G
Genevieve Losonsky
Researcher at University of Maryland, Baltimore
Publications - 130
Citations - 12620
Genevieve Losonsky is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Vaccination & Immunogenicity. The author has an hindex of 64, co-authored 130 publications receiving 12339 citations. Previous affiliations of Genevieve Losonsky include Walter Reed Army Institute of Research & University of Maryland, College Park.
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Journal ArticleDOI
Toxin, toxin-coregulated pili, and the toxR regulon are essential for Vibrio cholerae pathogenesis in humans.
TL;DR: Results show for the first time the role of a specific pilus structure in colonization of the human intestine by V. cholerae O1 and exemplify the significance of a genetic regulon in pathogenesis.
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Immunogenicity in humans of a recombinant bacterial antigen delivered in a transgenic potato.
Carol O. Tacket,Hugh S. Mason,Genevieve Losonsky,John D. Clements,Myron M. Levine,Charles J. Arntzen +5 more
TL;DR: The present study was conducted as a proof of principle to determine if humans would also develop a serum and/or mucosal immune response to an antigen delivered in an uncooked foodstuff.
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Safety and immunogenicity in man of a synthetic peptide malaria vaccine against plasmodium falciparum sporozoites
D A Herrington,David F. Clyde,Genevieve Losonsky,Manuel Cortesia,James R. Murphy,Jonathan R. Davis,Shahida Baqar,Arthur Felix,Edgar P. Heimer,Dieter Gillessen,Elizabeth Nardin,Ruth S. Nussenzweig,Victor Nussenzweig,M. R. Hollingdale,Myron M. Levine +14 more
TL;DR: This first synthetic peptide parenteral vaccine against a communicable disease tested in man is safe and stimulates biologically active antibodies, which encourage the development of improved vaccine formulations which, by enhancing immunogenicity, may lead to practical vaccines to assist in the control of falciparum malaria.
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Human immune responses to a novel norwalk virus vaccine delivered in transgenic potatoes
Carol O. Tacket,Hugh S. Mason,Genevieve Losonsky,Mary K. Estes,Myron M. Levine,Charles J. Arntzen +5 more
TL;DR: Norwalk virus capsid protein was used as a test antigen, to determine whether immune responses could be generated in volunteers who ingested transgenic potatoes, and 19 of 20 volunteers developed an immune response of some kind, although the level of serum antibody increases was modest.
Journal ArticleDOI
Role of the eaeA gene in experimental enteropathogenic Escherichia coli infection.
Michael S. Donnenberg,C O Tacket,Stephen P. James,Genevieve Losonsky,James P. Nataro,Steven S. Wasserman,J B Kaper,Myron M. Levine +7 more
TL;DR: This study unambiguously assigns a role for eaeA as an EPEC virulence gene, but the residual diarrhea seen in recipients of the mutant indicates that other factors are involved.