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Showing papers by "Arthur H. Moser published in 2002"

Journal Article•DOI•
Reduction in cytochrome P-450 enzyme expression is associated with repression of CAR (constitutive androstane receptor) and PXR (pregnane X receptor) in mouse liver during the acute phase response.

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Anne P. Beigneux1, Arthur H. Moser1, Judy K. Shigenaga1, Carl Grunfeld1, Kenneth R. Feingold1 •
University of California, San Francisco1
26 Apr 2002-Biochemical and Biophysical Research Communications
TL;DR: Injection of bacterial lipopolysaccharide (LPS) induced the expected reduction in Cyp2b10 and Cyp3a mRNA levels in mouse liver and observed a concomitant decrease in RXR (retinoid X receptor) mRNA levels, the obligatory partner of both CAR and PXR for high affinity binding to DNA.

189 citations

Journal Article•DOI•
Oxysterol stimulation of epidermal differentiation is mediated by liver X receptor-β in murine epidermis

[...]

László G. Kömüves1, Matthias Schmuth2, Matthias Schmuth1, Ashley J. Fowler2, Ashley J. Fowler1, Peter M. Elias1, Peter M. Elias2, Karen Hanley2, Karen Hanley1, Mao-Qiang Man1, Mao-Qiang Man2, Arthur H. Moser2, Jean-Marc A. Lobaccaro3, Mary L. Williams1, David J. Mangelsdorf3, Kenneth R. Feingold •
University of California, San Francisco1, United States Department of Veterans Affairs2, Howard Hughes Medical Institute3
01 Jan 2002-Journal of Investigative Dermatology
TL;DR: The ability of oxysterols to reverse epidermal hyperplasia suggests that these agents could be beneficial for the treatment of skin disorders associated with hyperproliferation and/or altered differentiation.

90 citations