Showing papers by "Arthur I. Cederbaum published in 1975"
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TL;DR: To study possible factors in the pathogenesis of the ethanol-induced fatty liver, the effect of chronic ethanol consumption on the metabolism of fatty acids by isolated hepatic mitochondria was investigated and beta oxidation to the level of acetyl-CoA is not impaired by chronicanol consumption.
84 citations
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TL;DR: The depression of the end products of fatty acid oxidation as well as the greater sensitivity of palmitate oxidation compared to acetate oxidation, suggests inhibition by acetaldehyde of β-oxidation, citric acid cycle activity, and the respiratory-phosphorylation chain.
55 citations
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TL;DR: The liver and hepatoma enzymes differ in electrophoretic mobility, susceptibility to heat treatment, pH activity optimum and some catalytic properties, and the overall substrate specificity characteristics are similar to those of the liver enzyme.
50 citations
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TL;DR: A bleeding diathesis is described which is phenotypically indistinguishable from hemophilia A and which has been transmitted as a dominant trait in three generations of women in a North Carolina kindred and six possible genetic explanations are entertained.
22 citations
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TL;DR: It is suggested that acetate causes a redistribution of the end products of palmitate oxidation toward ketogenesis rather than toward total oxidation to CO2 and H2O, whereas the oxidation of octanoate dilutes the CO2 produced from labeled acetate.
12 citations