Showing papers in "Blood in 1975"

TL;DR: This CML cell-line represents a unique source of CML cells with meaningful indicators of malignancy for clinical and experimental studies.

TL;DR: The proposed staging system was an equally accurate indicator for survival when applied to two other previously published studies of large series of patients and sex and age were shown to be poor predictors of survival after adjustment for stage.

TL;DR: Selective kinning cells in DNA synthesis using the tritiated thymidine suicide technique, in vivo, showed that CFU, near the bone surface are proliferating at a faster rate than those more distant from bone, but thatCFU have a fast proliferation rate irrespective of their position in the distribution.

TL;DR: The improved reproducibility, accuracy, and convenience of this method over existing methods should facilitate the collection of more meaningful information about circulating basophil levels in health and disease.

TL;DR: The proposed thesis that platelet size heterogeneity results mainly from aging in the circulation was contradicted by size distributions of age-homogeneous, newly-born cell populations which were lognormal with increased (instead of decreased) dispersion of volumes and the macrothrombocytosis found in some populations with normal age distribution.

TL;DR: A strong linear correlation between the amount of Hb F and proportion of F-cells was observed and this technique may prove useful in studies of a variety of disorders associated with HB F elevations and also in investigations of the mechanisms controlling the transition from fetal to adult hemoglobin during the course of human development.

TL;DR: Reducing the surface charge of human, rat, and rabbit erythrocytes by removing sialic acid with neuraminidase suggests that reduction in ERYthrocyte sIALic acid is a mechanism of ery throatcyte destruction and may be important in ery Throcyte senescence.

TL;DR: When available, early histocompatible bone marrow transplantation may be the treatment of choice for severe aplastic anemia and further delay increases risks of fatal complications and decreases chances for successful transplantation while the incidence of spontaneous remission declines.

TL;DR: In general, platelets stored in PE containers have excellent viability in vivo although CO2 escape can result in elevations in pH which are deleterious, although storage in a 10% CO2 atmosphere prevents these deletrrious pH elevations without otherwise impairing platelet viability.

TL;DR: These studies indicated that hydrocortisone administration caused a transient lymphocytopenia by a preferential depletion of the recirculating portion of the intravascular lymphocyte pool.

TL;DR: Experimental data indicate that plastic flow of the membranes under conditions of protracted strain may lead to permanent deformation of the membrane, whereas uniform dilation of the Membrane, requir- ing over 1000 times more energy than for plastic flow, results in membrane failure and lysis.

TL;DR: In six patients with acute leukemia the blast cells invading bone marrow and blood showed all the cytologic, cytochemical, and electron microscopy features of Burkitt's tumor cells, documenting the monoclonal B-cell origin of these blast cells which is in sharp contrast to the findings in common acute lymphoblastic leukemia.

TL;DR: A phylogenetic comparison of enzyme levels in animal and human PMN was undertaken; marked interspecies differences in enzyme activity were found; many species were deficient in alkaline phosphatase or lysozyme.

TL;DR: It is concluded that adrenaline, thrombin, 5HT, and vasopressin each can induce primary aggregation of human platelets by a mechanism independent of extracellular ADP.

TL;DR: Deletion of each component of the system, preheating the peroxidase, or addition of azide, cyanide, or catalase abolished the cytotoxicity.

TL;DR: The studies suggest that there is an intraerythrocytic response to the anemia in this group of patients, document that reduced ESF production is not a uniform finding with theAnemia of chronic disorders, and provide evidence that the marrow proliferative response to anemia is limited in many patients primarily by the availability of iron.

TL;DR: Five patients, four women and one man, age 32-8- yr, all whites, had refractory anemia with the same abnormal bone marrow karyotype, i.e., a partial deletion of the long arm of the No. 5 chromosome, which constitutes another example of the association between a specific abnormal chromosome and a distinct hematologic disorder.

TL;DR: Platelet aggregation occurred when heparin was added to the patient9s platelet-rich plasma, or to normal platelets plus the patient8s serum, and this pattern of aggregation was clearly different from that occasionally caused by Heparin in a control population.

TL;DR: It is postulated that the poor post-transfusion platelet increments obtained when standard platelet concentrates are used result from the leukoagglutinin antigen-antibody reaction involving the platelet as an "innocent bystander."

TL;DR: A toxic syndrome characterized by fever, headache, and vomiting, lasting 2-5 days, occurred in 61% of 39 children with acute leukemia in complete remission, receiving central nervous system prophylaxis with intrathecal methotrexate and in 14% of 34 children receiving the same plus cranial radiation.

TL;DR: A remarkable attenuation and fenestration of the endothelium associated with platelet depletion and increased permeability to colloids, as revealed by the transmural passage of Thorotrast is observed.

TL;DR: The absolute levels of kinase and deaminase and the ratio of these two enzymes varied considerably among patients with AML, indicating that quantitative differences may be found in the metabolism of CdR and its analogs in leukemic cells.

TL;DR: The major factor in residual lesions produced in mice by busulfan is a lesions of the stem cell itself, but an additional minor factor may be a lesion of the marrow environment.

TL;DR: The present studies support the contention that adult PRCA is an autoimmune disease and it is postulated that IgG serum autoantibodies, directed against either an early erythroid precursor or, more rarely, circulating Ep in PRCA type B, play a major role in the pathogenesis of the disease.

TL;DR: In vivo hairy cell leukemia cells had the capacity to adhere firmly to plastic, making it possible to obtain a pure population of hairy cells, but neither T-rosette formation nor phytohemagglutinin (PHA) transformation could be demonstrated in these cells.

TL;DR: A new form of hereditary persistence of fetal hemoglobin (HPFH) producing 3%-8% Hb F in heterozygotes and an elevation of F-cell counts as measured by both the Kleihauer test and an antibody fluorescent procedure was found during the study of a black family.

TL;DR: Patients with IgG multiple myeloma underwent serial studies of tumor cell kinetics, which suggested that the long “plateau” phase of partial remission in these patients was associated with a continued high LI, which suggests that the plateau resulted from a balance between the cytoreductive effects of chemotherapy and expansion of the growth fraction of the tumor.

TL;DR: In this article, a study was carried out on the effect of a number of inhibitors as well as of anaerobiosis on the production of superoxide (O2 minus) by granulocytes.

TL;DR: The data suggest that a greater number of erythropoietin-responsive cells are available for ESF to differentiate into the nucleated erythroid cell line in the presence of testosterone, indicating that the effect of a combination of testosterone and ESF is greater in enhancing erythyroid colony formation than the additive effects of either agent alone.

TL;DR: Although this method of prognostication needs further testing, if validated, it may prove useful in selecting patients for therapeutic trials and could explain the divergent results in previous studies of androgen treatment of aplastic anemia.