Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries
Giacomo Bellani,John G. Laffey,John G. Laffey,Tài Pham,Tài Pham,Eddy Fan,Eddy Fan,Laurent Brochard,Laurent Brochard,Andrés Esteban,Luciano Gattinoni,Frank van Haren,Anders Larsson,Daniel F. McAuley,Marco Ranieri,Gordon D. Rubenfeld,Gordon D. Rubenfeld,B. Taylor Thompson,Hermann Wrigge,Arthur S. Slutsky,Antonio Pesenti +20 more
TLDR
Clinician recognition of ARDS was associated with higher PEEP, greater use of neuromuscular blockade, and prone positioning, which indicates the potential for improvement in the management of patients with ARDS.Abstract:
IMPORTANCE Limited information exists about the epidemiology, recognition, management, and outcomes of patients with the acute respiratory distress syndrome (ARDS). OBJECTIVES To evaluate intensive ...read more
Citations
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Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study.
Xiaobo Yang,Yuan Yu,Jiqian Xu,Huaqing Shu,Jia'an Xia,Hong Liu,Hong Liu,Yongran Wu,Lu Zhang,Zhui Yu,Minghao Fang,Ting Yu,Yaxin Wang,Shangwen Pan,Xiaojing Zou,Shiying Yuan,You Shang,You Shang +17 more
TL;DR: The clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia who were admitted to the intensive care unit (ICU) of Wuhan Jin Yin-tan hospital between late December, 2019 and Jan 26, 2020 are described.
Journal ArticleDOI
Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: prospective cohort study.
Christopher M. Petrilli,Simon Jones,Jie Yang,Harish Rajagopalan,Luke J. D. O'Donnell,Yelena Chernyak,Katie A Tobin,Robert J. Cerfolio,Fritz Francois,Leora I. Horwitz +9 more
TL;DR: Age and comorbidities were found to be strong predictors of hospital admission and to a lesser extent of critical illness and mortality in people with coronavirus disease 2019 in the United States; however, impairment of oxygen on admission and markers of inflammation were most strongly associated with critical illnesses and mortality.
Journal ArticleDOI
Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome
Alain Combes,David Hajage,Gilles Capellier,Alexandre Demoule,Sylvain Lavoué,Christophe Guervilly,Daniel da Silva,Lara Zafrani,Patrice Tirot,Benoit Veber,Eric Maury,Bruno Levy,Yves Cohen,Christian Richard,Pierre Kalfon,Lila Bouadma,Hossein Mehdaoui,Gaetan Beduneau,Guillaume Lebreton,Laurent Brochard,Niall D. Ferguson,Eddy Fan,Arthur S. Slutsky,Daniel Brodie,Alain Mercat +24 more
TL;DR: Among patients with very severe ARDS, 60‐day mortality was not significantly lower with ECMO than with a strategy of conventional mechanical ventilation that included ECMO as rescue therapy, and fewer cases of ischemic stroke.
Journal ArticleDOI
Intensive care management of coronavirus disease 2019 (COVID-19): challenges and recommendations.
Jason Phua,Li Weng,Lowell Ling,Moritoki Egi,Chae Man Lim,Jigeeshu V Divatia,Babu Raja Shrestha,Yaseen M. Arabi,Jensen Ng,Charles D. Gomersall,Masaji Nishimura,Younsuck Koh,Bin Du +12 more
TL;DR: Streamlining of workflows for rapid diagnosis and isolation, clinical management, and infection prevention will matter not only to patients with COVID-19, but also to health-care workers and other patients who are at risk from nosocomial transmission.
Journal ArticleDOI
Risk factors associated with mortality among patients with COVID-19 in intensive care units in Lombardy, Italy
Giacomo Grasselli,Massimiliano Greco,Alberto Zanella,G. Albano,Massimo Antonelli,Giacomo Bellani,E. Bonanomi,Luca Cabrini,Eleonora Carlesso,Gian Paolo Castelli,S. Cattaneo,Danilo Cereda,S. Colombo,A. Coluccello,G. Crescini,A. Forastieri Molinari,Giuseppe Foti,Roberto Fumagalli,Giorgio Antonio Iotti,Thomas Langer,Nicola Latronico,F. L. Lorini,Francesco Mojoli,Giuseppe Natalini,C. M. Pessina,Vito Marco Ranieri,R. Rech,Luigia Scudeller,Antonio Rosano,Enrico Storti,B. T. Thompson,Marcello Tirani,Paola Villani,Antonio Pesenti,Maurizio Cecconi +34 more
TL;DR: The independent risk factors associated with mortality were evaluated with a multivariable Cox proportional hazards regression and infection with severe acute respiratory syndrome coronavirus 2 was confirmed by real-time reverse transcriptase-polymerase chain reaction assay of nasopharyngeal swabs.
References
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The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies
Erik von Elm,Douglas G. Altman,Matthias Egger,Matthias Egger,Stuart J. Pocock,Peter C Gøtzsche,Jan P. Vandenbroucke +6 more
TL;DR: The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Initiative developed recommendations on what should be included in an accurate and complete report of an observational study, resulting in a checklist of 22 items that relate to the title, abstract, introduction, methods, results, and discussion sections of articles.
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TL;DR: The updated and revised Berlin Definition for ARDS addresses a number of the limitations of the AECC definition and may serve as a model to create more accurate, evidence-based, critical illness syndrome definitions and to better inform clinical care, research, and health services planning.
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TL;DR: The acute respiratory distress syndrome (ARDS), a process of nonhydrostatic pulmonary edema and hypoxemia associated with a variety of etiologies, carries a high morbidity, mortality, and financial cost.
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