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Keiji Kuba
Researcher at Akita University
Publications - 71
Citations - 11904
Keiji Kuba is an academic researcher from Akita University. The author has contributed to research in topics: Angiotensin-converting enzyme 2 & Angiotensin II. The author has an hindex of 31, co-authored 59 publications receiving 9611 citations. Previous affiliations of Keiji Kuba include Austrian Academy of Sciences & National Presto Industries.
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Journal ArticleDOI
A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury
Keiji Kuba,Yumiko Imai,Shuan Rao,Hong Gao,Feng Guo,Bin Guan,Yi Huan,Peng Yang,Yanli Zhang,Wei Deng,Linlin Bao,Binlin Zhang,Guang Liu,Zhong Wang,Mark C. Chappell,Yanxin Liu,Dexian Zheng,Andreas Leibbrandt,Teiji Wada,Arthur S. Slutsky,Depei Liu,Chuan Qin,Chengyu Jiang,Josef M. Penninger +23 more
TL;DR: A molecular explanation why SARS-CoV infections cause severe and often lethal lung failure and suggest a rational therapy for SARS and possibly other respiratory disease viruses is provided.
Journal ArticleDOI
Angiotensin-converting enzyme 2 protects from severe acute lung failure
Yumiko Imai,Keiji Kuba,Shuan Rao,Yi Huan,Feng Guo,Bin Guan,Peng Yang,Renu Sarao,Teiji Wada,Howard Leong-Poi,Michael A. Crackower,Akiyoshi Fukamizu,Chi-chung Hui,Lutz Hein,Stefan Uhlig,Arthur S. Slutsky,Chengyu Jiang,Josef M. Penninger +17 more
TL;DR: It is reported that ACE2 and the angiotensin II type 2 receptor (AT2) protect mice from severe acute lung injury induced by acid aspiration or sepsis, pointing to a possible therapy for a syndrome affecting millions of people worldwide every year.
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Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury
Yumiko Imai,Keiji Kuba,Keiji Kuba,G. Greg Neely,Rubina Yaghubian-Malhami,Thomas Perkmann,Geert van Loo,Maria A. Ermolaeva,Maria A. Ermolaeva,Ruud A. W. Veldhuizen,Y.H. Connie Leung,Hongliang Wang,Haolin Liu,Yang Sun,Manolis Pasparakis,Manolis Pasparakis,Manfred Kopf,Christin Mech,Sina Bavari,J. S. Malik Peiris,Arthur S. Slutsky,Shizuo Akira,Malin Hultqvist,Rikard Holmdahl,John M. Nicholls,Chengyu Jiang,Christoph J. Binder,Josef M. Penninger +27 more
TL;DR: It is reported that Toll-like receptor 4 (TLR4) mutant mice display natural resistance to acid-induced acute lung injury (ALI), and it is shown that TLR4-TRIF-TRAF6 signaling is a key disease pathway that controls the severity of ALI.
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ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation
Tatsuo Hashimoto,Thomas Perlot,Ateequr Rehman,Ateequr Rehman,Jean Trichereau,Hiroaki Ishiguro,Magdalena Paolino,Verena Sigl,Toshikatsu Hanada,Reiko Hanada,Simone Lipinski,Birgit Wild,Simone M. R. Camargo,Dustin Singer,Andreas Richter,Keiji Kuba,Akiyoshi Fukamizu,Stefan Schreiber,Hans Clevers,François Verrey,Philip Rosenstiel,Josef M. Penninger +21 more
TL;DR: The results identify ACE2 as a key regulator of dietary amino acid homeostasis, innate immunity, gut microbial ecology, and transmissible susceptibility to colitis, providing a molecular explanation for how amino acid malnutrition can cause intestinal inflammation and diarrhoea.
Journal ArticleDOI
The Lipid Mediator Protectin D1 Inhibits Influenza Virus Replication and Improves Severe Influenza
Masayuki Morita,Keiji Kuba,Akihiko Ichikawa,Mizuho Nakayama,Jun Katahira,Ryo Iwamoto,Tokiko Watanebe,Tokiko Watanebe,Saori Sakabe,Saori Sakabe,Tomo Daidoji,Shota Nakamura,Ayumi Kadowaki,Takayo Ohto,Hiroki Nakanishi,Ryo Taguchi,Takaaki Nakaya,Makoto Murakami,Yoshihiro Yoneda,Hiroyuki Arai,Yoshihiro Kawaoka,Yoshihiro Kawaoka,Josef M. Penninger,Makoto Arita,Makoto Arita,Yumiko Imai +25 more
TL;DR: Using mediator lipidomics and bioactive lipid screen, it is reported that the omega-3 polyunsaturated fatty acid-derived lipid mediator protectin D1 (PD1) markedly attenuated influenza virus replication via RNA export machinery.