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Arturo Andrade
Researcher at University of New Hampshire
Publications - 29
Citations - 880
Arturo Andrade is an academic researcher from University of New Hampshire. The author has contributed to research in topics: Voltage-dependent calcium channel & Alternative splicing. The author has an hindex of 17, co-authored 28 publications receiving 723 citations. Previous affiliations of Arturo Andrade include CINVESTAV & Instituto Politécnico Nacional.
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Journal ArticleDOI
Alternative splicing: Functional diversity among voltage-gated calcium channels and behavioral consequences
TL;DR: Altered patterns of alternative splicing of Ca(V) pre-mRNAs can alter behavior in subtle but measurable ways, with the potential to influence drug efficacy and disease severity.
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Opioid inhibition of N-type Ca2+ channels and spinal analgesia couple to alternative splicing.
TL;DR: It is shown that mutually exclusive splicing patterns in the CaV2.2 gene modulate N-type channel function in nociceptors, leading to a change in morphine analgesia, and that highly specialized, discrete cellular responsiveness in vivo can be attributed to alternative splicing events regulated at the level of individual neurons.
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CACNA1B mutation is linked to unique myoclonus-dystonia syndrome
Justus L. Groen,Arturo Andrade,Katja Ritz,Hamid Jalalzadeh,Martin A. Haagmans,Ted E.J. Bradley,Aldo Jongejan,Dineke S. Verbeek,Peter Nürnberg,Sylvia Denome,Raoul C.M. Hennekam,Diane Lipscombe,Frank Baas,Marina A. J. Tijssen +13 more
TL;DR: Using exome sequencing and linkage analysis in a three-generation family with a unique dominant myoclonus-dystonia-like syndrome with cardiac arrhythmias, a mutation in the CACNA1B gene, coding for neuronal voltage-gated calcium channels CaV 2.2.2 channels was identified.
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Genetic Associations between Voltage-Gated Calcium Channels and Psychiatric Disorders.
Arturo Andrade,Ashton Brennecke,Shayna Mallat,Julian Brown,Juan Gomez-Rivadeneira,Natalie Czepiel,Laura Londrigan +6 more
TL;DR: A general overview of CaVs structure, classification, function, expression and pharmacology, and pharmacological evidence of the use of CaV modulators to treat psychiatric disorders are provided.
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A rare schizophrenia risk variant of CACNA1I disrupts Ca V 3.3 channel activity
TL;DR: In this paper, the pore-forming human CaV3.3 α1 subunit, a subtype of voltage-gated calcium channel that contributes to T-type currents, was identified in individuals with schizophrenia.