Marina A. J. Tijssen

TL;DR: The basal ganglia may receive multiple cortical inputs at frequencies <30 Hz and, in the presence of dopaminergic activity, produce a high frequency drive back to the cerebral cortex, in particular the supplementary motor area (SMA).

TL;DR: Functional studies and structural analysis of the protein suggest that six missense mutations in the gene for the Na+/K+ -ATPase alpha3 subunit (ATP1A3) impair enzyme activity or stability in RDP, and implicates the Na-K+ pump, a crucial protein responsible for the electrochemical gradient across the cell membrane, in dystonia and parkinsonism.

TL;DR: In comparing ATP1A3 mutation positive and negative patients, it is found that tremor at onset of symptoms, a reversed rostrocaudal gradient, and significant limb pain exclude a diagnosis of RDP.

TL;DR: In this article, a double-blind randomized cross-over trial assessing the efficacy and safety of stimulation of the centromedian nucleus-substantia periventricularis-nucleus ventro-oralis internus crosspoint in the thalamus was conducted.

TL;DR: In this paper, the extent to which functional circuits coupling cortical and sub-thalamic activity are multiple and segregated by frequency in untreated Parkinson's disease (PD) was investigated, where EEG and local field potentials (LFPs) from macroelectrodes inserted into the subthalamic nucleus area (SA) in nine awake patients following functional neurosurgery for PD were studied after overnight withdrawal of medication.