J
Jonathan J. Hansen
Researcher at University of North Carolina at Chapel Hill
Publications - 52
Citations - 4640
Jonathan J. Hansen is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Colitis & Transduction (genetics). The author has an hindex of 24, co-authored 48 publications receiving 4076 citations. Previous affiliations of Jonathan J. Hansen include IU Health University Hospital & Indiana University.
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Journal ArticleDOI
Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota
Janelle C. Arthur,Ernesto Perez-Chanona,Marcus Mühlbauer,Sarah Tomkovich,Joshua M. Uronis,Ting Jia Fan,Barry J. Campbell,Turki S. Abujamel,Turki S. Abujamel,Belgin Dogan,Arlin B. Rogers,Jonathan M. Rhodes,Alain Stintzi,Kenneth W. Simpson,Jonathan J. Hansen,Temitope O. Keku,Anthony A. Fodor,Christian Jobin +17 more
TL;DR: High-throughput sequencing revealed that inflammation modifies gut microbial composition in colitis-susceptible interleukin-10–deficient (Il10−/−) mice, suggesting that in mice, colitis can promote tumorigenesis by altering microbial composition and inducing the expansion of microorganisms with genotoxic capabilities.
PatentDOI
Human fibroblast growth factor receptor 1 is a co-receptor for infection by adeno-associated virus 2
TL;DR: In this paper, it was shown that AAV requires human fibroblast growth factor receptor 1 (FGFR1) as a co-receptor for successful viral entry into the host cell.
Journal ArticleDOI
Adeno-associated virus 2 co-receptors?-first reply
TL;DR: The absolute requirement for the deliberate expression of both HSPG and FGFR1 in Raji cells, which are known to lack expression of these genes, to render these cells permissive for AAV infection, strongly supports the contention that both Hparan sulfate proteoglycan andFGFR1 serve as coreceptors for A AV.
Journal ArticleDOI
Propofol versus midazolam/fentanyl for outpatient colonoscopy: administration by nurses supervised by endoscopists.
Brian J. Ulmer,Jonathan J. Hansen,Christine A Overley,Michelle Symms,Vidyasree Chadalawada,Suthat Liangpunsakul,Eloise Strahl,April M. Mendel,Douglas K. Rex +8 more
TL;DR: Nurse-administered propofol resulted in several advantages for outpatient colonoscopy compared with midazolam plus fentanyl, but did not improve patient satisfaction.
Journal ArticleDOI
The role of mucosal immunity and host genetics in defining intestinal commensal bacteria.
TL;DR: Understanding of mechanisms by which commensal bacteria are controlled and shaped into functional communities by innate and adaptive immune responses, antimicrobial peptides produced by epithelial cells and host genetic factors should help develop strategies to correct dysfunctional altered microbiota in genetically susceptible individuals.