A
Arunachalam Chinnathambi
Researcher at King Saud University
Publications - 199
Citations - 4497
Arunachalam Chinnathambi is an academic researcher from King Saud University. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 27, co-authored 148 publications receiving 2502 citations. Previous affiliations of Arunachalam Chinnathambi include University of Sheffield.
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Journal ArticleDOI
The Multifaceted Role of Curcumin in Cancer Prevention and Treatment
Muthu K. Shanmugam,Grishma Rane,Madhu Mathi Kanchi,Frank Arfuso,Arunachalam Chinnathambi,M. E. Zayed,Sulaiman Ali Alharbi,Benny K. H. Tan,Alan Prem Kumar,Gautam Sethi,Gautam Sethi,Gautam Sethi +11 more
TL;DR: The current review focuses on the diverse molecular targets modulated by curcumin that contribute to its efficacy against various human cancers.
Journal ArticleDOI
NF‑κB in cancer therapy
Feng Li,Jingwen Zhang,Frank Arfuso,Arunachalam Chinnathambi,M. E. Zayed,Sulaiman Ali Alharbi,Alan Prem Kumar,Kwang Seok Ahn,Gautam Sethi,Gautam Sethi,Gautam Sethi +10 more
TL;DR: The diverse molecular mechanism(s) by which the NF-κB pathway is constitutively activated in different types of human cancers, and the potential role of various oncogenic genes regulated by this transcription factor in cancer development and progression are highlighted.
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Targeting TNF-related apoptosis-inducing ligand (TRAIL) receptor by natural products as a potential therapeutic approach for cancer therapy.
Xiaoyun Dai,Jingwen Zhang,Frank Arfuso,Arunachalam Chinnathambi,M. E. Zayed,Sulaiman Ali Alharbi,Alan Prem Kumar,Kwang Seok Ahn,Gautam Sethi +8 more
TL;DR: Both apoptotic and nonapoptotic pathways activated by TRAIL are summarized, as well as recent advances in developing TRAIL–receptor agonists for cancer therapy.
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Isorhamnetin augments the anti-tumor effect of capeciatbine through the negative regulation of NF-κB signaling cascade in gastric cancer
Kanjoormana Aryan Manu,Muthu K. Shanmugam,Lalitha Ramachandran,Feng Li,Kodappully Sivaraman Siveen,Arunachalam Chinnathambi,M. E. Zayed,Sulaiman Ali Alharbi,Frank Arfuso,Alan Prem Kumar,Kwang Seok Ahn,Gautam Sethi,Gautam Sethi,Gautam Sethi +13 more
TL;DR: Results demonstrate that isorhamnetin can significantly enhance the anti-tumor effects of capecitabine through the negative regulation of NF-κB regulated oncogenic genes.
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Thymoquinone Inhibits Bone Metastasis of Breast Cancer Cells Through Abrogation of the CXCR4 Signaling Axis.
Muthu K. Shanmugam,Kwang Seok Ahn,Annie Hsu,Chern Chiuh Woo,Yi Yuan,Kwong Huat Benny Tan,Arunachalam Chinnathambi,Tahani Awad Alahmadi,Sulaiman Ali Alharbi,Angele Pei-Fern Koh,Frank Arfuso,Ruby Yun-Ju Huang,Lina H. K. Lim,Gautam Sethi,Alan Prem Kumar +14 more
TL;DR: The results indicate that TQ primarily exerts its anti-metastatic effects by down-regulation of NF-κB regulated CXCR4 expression and thus has potential for the treatment of breast cancer.