M
Muthu K. Shanmugam
Researcher at National University of Singapore
Publications - 113
Citations - 10468
Muthu K. Shanmugam is an academic researcher from National University of Singapore. The author has contributed to research in topics: Cancer & STAT3. The author has an hindex of 53, co-authored 111 publications receiving 7801 citations. Previous affiliations of Muthu K. Shanmugam include University Health System.
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Journal ArticleDOI
The E-Cadherin and N-Cadherin Switch in Epithelial-to-Mesenchymal Transition: Signaling, Therapeutic Implications, and Challenges.
Chin-Yap Loh,Jian Yi Chai,Ting Fang Tang,Won Fen Wong,Gautam Sethi,Muthu K. Shanmugam,Pei Pei Chong,Chung Yeng Looi +7 more
TL;DR: The recent understanding of the roles of E- and N-cadherins in cancer invasion and metastasis as well as the crosstalk with other signaling pathways involved in EMT is summarized.
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The Role of Resveratrol in Cancer Therapy
Jeong-Hyeon Ko,Gautam Sethi,Jae-Young Um,Muthu K. Shanmugam,Frank Arfuso,Alan Prem Kumar,Anupam Bishayee,Kwang Seok Ahn +7 more
TL;DR: The current focus of this review is resveratrol’s in vivo and in vitro effects in a variety of cancers, and intracellular molecular targets modulated by this polyphenol.
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The Multifaceted Role of Curcumin in Cancer Prevention and Treatment
Muthu K. Shanmugam,Grishma Rane,Madhu Mathi Kanchi,Frank Arfuso,Arunachalam Chinnathambi,M. E. Zayed,Sulaiman Ali Alharbi,Benny K. H. Tan,Alan Prem Kumar,Gautam Sethi,Gautam Sethi,Gautam Sethi +11 more
TL;DR: The current review focuses on the diverse molecular targets modulated by curcumin that contribute to its efficacy against various human cancers.
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Molecular targets of celastrol derived from Thunder of God Vine: Potential role in the treatment of inflammatory disorders and cancer
TL;DR: Celastrol's ability to modulate the expression of pro-inflammatory cytokines, MHC II, HO-1, iNOS, NF-κB, Notch- 1, AKT/mTOR, CXCR4, TRAIL receptors DR4 and DR5, CHOP, JNK, VEGF, adhesion molecules, proteasome activity, potassium channels, and heat shock response has been reported.
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Multifaceted link between cancer and inflammation
TL;DR: The present review will focus primarily on the role of various inflammatory intermediates responsible for tumour initiation and progression, and discuss in detail the critical link between inflammation and cancer.