Targeting TNF-related apoptosis-inducing ligand (TRAIL) receptor by natural products as a potential therapeutic approach for cancer therapy.
Xiaoyun Dai,Jingwen Zhang,Frank Arfuso,Arunachalam Chinnathambi,M. E. Zayed,Sulaiman Ali Alharbi,Alan Prem Kumar,Kwang Seok Ahn,Gautam Sethi +8 more
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TLDR
Both apoptotic and nonapoptotic pathways activated by TRAIL are summarized, as well as recent advances in developing TRAIL–receptor agonists for cancer therapy.Citations
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Evidence for the Involvement of the Master Transcription Factor NF-κB in Cancer Initiation and Progression.
Yu Rou Puar,Muthu K. Shanmugam,Lu Fan,Frank Arfuso,Gautam Sethi,Vinay Tergaonkar,Vinay Tergaonkar,Vinay Tergaonkar +7 more
TL;DR: Although NF-κB has been identified to be a major contributor to cancer initiation and development, there is evidence revealing its role in tumor suppression, as well as a few important pharmacological strategies that have been developed to modulate NF-σB function.
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Curcumin Delivery Mediated by Bio-Based Nanoparticles: A Review.
Mahshid Moballegh Nasery,Mahshid Moballegh Nasery,Banafshe Abadi,Delaram Poormoghadam,Ali Zarrabi,Peyman Keyhanvar,Hashem Khanbabaei,Milad Ashrafizadeh,Reza Mohammadinejad,Shima Tavakol,Gautam Sethi +10 more
TL;DR: The manipulation and encapsulation of curcumin into a nanocarrier formulation can overcome these major drawbacks and potentially may lead to a far superior therapeutic efficacy.
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Regulation of Nuclear Factor-KappaB (NF-κB) signaling pathway by non-coding RNAs in cancer: Inhibiting or promoting carcinogenesis?
Sepideh Mirzaei,Ali Zarrabi,Farid Hashemi,Amirhossein Zabolian,Hossein Saleki,Adnan Ranjbar,Seyed Hesam Seyed Saleh,Morteza Bagherian,Seyed Omid Sharifzadeh,Kiavash Hushmandi,Alena Liskova,Peter Kubatka,Pooyan Makvandi,Vinay Tergaonkar,Alan Prem Kumar,Milad Ashrafizadeh,Gautam Sethi +16 more
TL;DR: In this paper, it has been shown that microRNAs (miRNAs) can dually inhibit/induce NF-κB signaling thereby affecting the growth and migration of cancer cells.
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Association of the Epithelial-Mesenchymal Transition (EMT) with Cisplatin Resistance.
Milad Ashrafizadeh,Ali Zarrabi,Kiavash Hushmandi,Kiavash Hushmandi,Mahshad Kalantari,Reza Mohammadinejad,Tahereh Javaheri,Gautam Sethi +7 more
TL;DR: The various targeted signaling pathways that could be considered in future studies to pave the way for the inhibition of EMT-mediated resistance displayed by tumor cells in response to CP exposure are highlighted.
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MicroRNAs in cancer cell death pathways: Apoptosis and necroptosis
Solmaz Shirjang,Behzad Mansoori,Samira Asghari,Pascal H.G. Duijf,Ali Mohammadi,Morten F. Gjerstorff,Behzad Baradaran +6 more
TL;DR: Better understanding the cancer type-specific expression of apoptomiRs and oncomiRs and their underlying mechanisms in cell death pathways will not only advance the knowledge, but also continue to provide new opportunities to treat cancer.
References
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Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
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An endotoxin-induced serum factor that causes necrosis of tumors
TL;DR: It is proposed that TNF mediates endotoxin-induced tumor necrosis, and that it may be responsible for the suppression of transformed cells by activated macrophages.
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Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors
TL;DR: The purification of a cytosolic protein that induces cytochrome c release from mitochondria in response to caspase-8, the apical caspases activated by cell surface death receptors such as Fas and TNF is reported.
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Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition.
TL;DR: The identification of a novel protein, Smac, which promotes caspase activation in the cytochrome c/Apaf-1/caspase-9 pathway and increases cells' sensitivity to apoptotic stimuli is reported.