Journal ArticleDOI
NF‑κB in cancer therapy
Feng Li,Jingwen Zhang,Frank Arfuso,Arunachalam Chinnathambi,M. E. Zayed,Sulaiman Ali Alharbi,Alan Prem Kumar,Kwang Seok Ahn,Gautam Sethi,Gautam Sethi,Gautam Sethi +10 more
TLDR
The diverse molecular mechanism(s) by which the NF-κB pathway is constitutively activated in different types of human cancers, and the potential role of various oncogenic genes regulated by this transcription factor in cancer development and progression are highlighted.Abstract:
The transcription factor nuclear factor kappa B (NF-κB) has attracted increasing attention in the field of cancer research from last few decades. Aberrant activation of this transcription factor is frequently encountered in a variety of solid tumors and hematological malignancies. NF-κB family members and their regulated genes have been linked to malignant transformation, tumor cell proliferation, survival, angiogenesis, invasion/metastasis, and therapeutic resistance. In this review, we highlight the diverse molecular mechanism(s) by which the NF-κB pathway is constitutively activated in different types of human cancers, and the potential role of various oncogenic genes regulated by this transcription factor in cancer development and progression. Additionally, various pharmacological approaches employed to target the deregulated NF-κB signaling pathway, and their possible therapeutic potential in cancer therapy is also discussed briefly.read more
Citations
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Journal ArticleDOI
The Role of Resveratrol in Cancer Therapy
Jeong-Hyeon Ko,Gautam Sethi,Jae-Young Um,Muthu K. Shanmugam,Frank Arfuso,Alan Prem Kumar,Anupam Bishayee,Kwang Seok Ahn +7 more
TL;DR: The current focus of this review is resveratrol’s in vivo and in vitro effects in a variety of cancers, and intracellular molecular targets modulated by this polyphenol.
Journal ArticleDOI
Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study.
TL;DR: This review attempts to summarize the current knowledge and updates on the mechanisms of NF-κB pathway regulation and the potential therapeutic application of inhibition of NF -κB signaling in cancer and inflammatory diseases.
Journal ArticleDOI
The multifaceted role of reactive oxygen species in tumorigenesis
TL;DR: The modulation of oxidative stress response might represent a potential approach to eradicate cancer in combination with FDA-approved chemotherapies, radiotherapie as well as immunotherapIES.
Journal ArticleDOI
Evidence for the Involvement of the Master Transcription Factor NF-κB in Cancer Initiation and Progression.
Yu Rou Puar,Muthu K. Shanmugam,Lu Fan,Frank Arfuso,Gautam Sethi,Vinay Tergaonkar,Vinay Tergaonkar,Vinay Tergaonkar +7 more
TL;DR: Although NF-κB has been identified to be a major contributor to cancer initiation and development, there is evidence revealing its role in tumor suppression, as well as a few important pharmacological strategies that have been developed to modulate NF-σB function.
Journal ArticleDOI
Pro-Apoptotic and Anti-Cancer Properties of Diosgenin: A Comprehensive and Critical Review
Gautam Sethi,Muthu K. Shanmugam,Sudha Warrier,Myriam Merarchi,Frank Arfuso,Alan Prem Kumar,Anupam Bishayee +6 more
TL;DR: The multifaceted anti-cancer properties of diosgenin that have found application in pharmaceutical, functional food, and cosmetic industries; and the various intracellular molecular targets modulated by diosdenin that abrogate the oncogenic process are discussed.
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