抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

This critical review provides a processing-structure-property perspective on recent advances in cellulose nanoparticles and composites produced from them. It summarizes cellulose nanoparticles in terms of particle morphology, crystal structure, and properties. Also described are the self-assembly and rheological properties of cellulose nanoparticle suspensions. The methodology of composite processing and resulting properties are fully covered, with an emphasis on neat and high fraction cellulose composites. Additionally, advances in predictive modeling from molecular dynamic simulations of crystalline cellulose to the continuum modeling of composites made with such particles are reviewed (392 references).

/pdf/cellulose-nanomaterials-review-structure-properties-and-2z8x922p3v.pdf

Cellulose nanomaterials review: structure, properties and nanocomposites

Intermolecular And Surface Forces

International Technology Roadmap for Semiconductors 2003の要求清浄度について － シリコンウエハ表面と雰囲気環境に要求される清浄度, 分析方法の現状について －

With the arising of global climate change and resource shortage, in recent years, increased attention has been paid to environmentally friendly materials. Trees are sustainable and renewable materials, which give us shelter and oxygen and remove carbon dioxide from the atmosphere. Trees are a primary resource that human society depends upon every day, for example, homes, heating, furniture, and aircraft. Wood from trees gives us paper, cardboard, and medical supplies, thus impacting our homes, school, work, and play. All of the above-mentioned applications have been well developed over the past thousands of years. However, trees and wood have much more to offer us as advanced materials, impacting emerging high-tech fields, such as bioengineering, flexible electronics, and clean energy. Wood naturally has a hierarchical structure, composed of well-oriented microfibers and tracheids for water, ion, and oxygen transportation during metabolism. At higher magnification, the walls of fiber cells have an interes...

https://www.fpl.fs.fed.us/documnts/pdf2016/fpl_2016_zhu001.pdf

Wood-Derived Materials for Green Electronics, Biological Devices, and Energy Applications.

We use Anderson or vibration localization in coupled microcantilevers as an extremely sensitive method to detect the added mass of a target analyte. We focus on the resonance frequencies and eigenstates of two nearly identical coupled gold-foil microcantilevers. Theoretical and experimental results indicate that the relative changes in the eigenstates due to the added mass can be orders of magnitude greater than the relative changes in resonance frequencies. Moreover this sensing paradigm possesses intrinsic common mode rejection characteristics thus providing an alternate way to achieve ultrasensitive mass detection under ambient conditions.

/pdf/ultrasensitive-mass-sensing-using-mode-localization-in-y13lktqqww.pdf

Ultrasensitive mass sensing using mode localization in coupled microcantilevers

Multi-harmonic atomic force microscopy can be used to map the local mechanical properties of live cells with better temporal and spatial resolution than has been achieved before.

Mapping nanomechanical properties of live cells using multi-harmonic atomic force microscopy.

Cellulose nanocrystals (CNCs) are gaining interest as a "green" nanomaterial with superior mechanical and chemical properties for high-performance nanocomposite materials; however, there is a lack of accurate material property characterization of individual CNCs. Here, a detailed study of the topography, elastic and adhesive properties of individual wood-derived CNCs is performed using atomic force microscopy (AFM). AFM experiments involving high-resolution dynamic mode imaging and jump-mode measurements were performed on individual CNCs under ambient conditions with 30% relative humidity (RH) and under a N(2) atmosphere with 0.1% RH. A procedure was also developed to calculate the CNC transverse elastic modulus (E(T)) by comparing the experimental force-distance curves measured on the CNCs with 3D finite element calculations of tip indentation on the CNC. The E(T) of an isolated CNC was estimated to be between 18 and 50 GPa at 0.1% RH; however, the associated crystallographic orientation of the CNC could not be determined. CNC properties were reasonably uniform along the entire CNC length, despite variations along the axis of 3-8 nm in CNC height. The range of RH used in this study was found to have a minimal effect on the CNC geometry, confirming the resistance of the cellulose crystals to water penetration. CNC flexibility was also investigated by using the AFM tip as a nanomanipulator.

https://www.fpl.fs.fed.us/documnts/pdf2010/fpl_2010_lahiji001.pdf

Atomic force microscopy characterization of cellulose nanocrystals.

The nonlinear dynamic response of atomic force microscopy cantilevers tapping on a sample is discussed through theoretical, computational, and experimental analysis. Experimental measurements are presented for the frequency response of a specific microcantilever-sample system to demonstrate the nonlinear features, including multiple jump phenomena leading to reproducible hysteresis. We show that a comprehensive analysis using modern continuation tools for computational nonlinear dynamics and bifurcation problems reproduces all essential features of the data. A close connection is established between the features of the interaction potential well and the nonlinear forced tip response. In particular, the effects of the nonlinear van der Waals forces, the nanoscale contact nonlinearities, and microcantilever damping, as well as the effects of forced and parametric excitation on the bifurcations and instabilities of forced periodic motions of the microcantilever system, are discussed in detail. The results indicate that nonlinear system identification methods could be used as effective tools to extract detailed information about the tip‐surface interaction potential.

/pdf/nonlinear-dynamics-of-microcantilevers-in-tapping-mode-3z1g4itzzm.pdf

Nonlinear dynamics of microcantilevers in tapping mode atomic force microscopy: A comparison between theory and experiment

The hydrodynamic loading of elastic microcantilevers vibrating in viscous fluids is analyzed computationally using a three-dimensional, finite element fluid-structure interaction model. The quality factors and added mass coefficients of several modes are computed accurately from the transient oscillations of the microcantilever in the fluid. The effects of microcantilever geometry, operation in higher bending modes, and orientation and proximity to a surface are analyzed in detail. The results indicate that in an infinite medium, microcantilever damping arises from localized fluid shear near the edges of the microcantilever. Closer to the surface, however, the damping arises due to a combination of squeeze film effects and viscous shear near the edges. The dependence of these mechanisms on microcantilever geometry and orientation in the proximity of a surface are discussed. The results provide a comprehensive understanding of the hydrodynamic loading of microcantilevers in viscous fluids and are expected to be of immediate interest in atomic force microscopy and microcantilever biosensors.

/pdf/hydrodynamic-loading-of-microcantilevers-vibrating-in-2xeu3uo1lg.pdf

Arvind Raman

Papers

Ultrasensitive mass sensing using mode localization in coupled microcantilevers

Mapping nanomechanical properties of live cells using multi-harmonic atomic force microscopy.

Atomic force microscopy characterization of cellulose nanocrystals.

Nonlinear dynamics of microcantilevers in tapping mode atomic force microscopy: A comparison between theory and experiment

Hydrodynamic loading of microcantilevers vibrating in viscous fluids