Å
Åsa Sjöling
Researcher at Karolinska Institutet
Publications - 94
Citations - 2856
Åsa Sjöling is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Enterotoxigenic Escherichia coli & Helicobacter pylori. The author has an hindex of 26, co-authored 85 publications receiving 2416 citations. Previous affiliations of Åsa Sjöling include University of Gothenburg & World Health Organization.
Papers
More filters
Journal ArticleDOI
Mucosal FOXP3-Expressing CD4+ CD25high Regulatory T Cells in Helicobacter pylori-Infected Patients
Anna Lundgren,E. Strömberg,Åsa Sjöling,Catharina Lindholm,Karin Enarsson,Anders Edebo,Erik Johnsson,Elisabeth Suri-Payer,Pia Larsson,Anna Rudin,Ann-Mari Svennerholm,B. Samuel Lundin +11 more
TL;DR: It is shown that H. pylori-infected individuals have increased frequencies of CD4+ CD25high T cells in both the stomach and duodenal mucosa compared to uninfected controls, suggesting that regulatory T cells may suppress mucosal immune responses and thereby contribute to the persistence of H.pylori infections.
Journal ArticleDOI
Identification of enterotoxigenic Escherichia coli (ETEC) clades with long-term global distribution
Astrid von Mentzer,Thomas R. Connor,Lothar H. Wieler,Torsten Semmler,Atsushi Iguchi,Nicholas R. Thomson,David A. Rasko,Enrique Joffré,Jukka Corander,Derek Pickard,Gudrun Wiklund,Ann-Mari Svennerholm,Åsa Sjöling,Gordon Dougan +13 more
TL;DR: Whole-genome sequencing of a representative collection of ETEC isolated between 1980 and 2011 identified globally distributed lineages characterized by distinct colonization factor and enterotoxin profiles that might harbor chromosome and plasmid combinations that optimize fitness and transmissibility.
Journal ArticleDOI
Comparative Analyses of Phenotypic and Genotypic Methods for Detection of Enterotoxigenic Escherichia coli Toxins and Colonization Factors
TL;DR: Established phenotypic and genotypic detection methods and newly developed PCR detection methods are compared with respect to sensitivity, specificity, positive predictive value, and ease of performance for Enterotoxigenic Escherichia coli.
Journal ArticleDOI
Oral Tolerance Induction with Antigen Conjugated to Cholera Toxin B Subunit Generates Both Foxp3+CD25+ and Foxp3−CD25− CD4+ Regulatory T Cells
TL;DR: It is demonstrated that oral tolerance induced by CTB-conjugated Ag is associated with increase in TGF-β and in both the frequency and suppressive capacity of Foxp3+ and CTLA-4+ CD25+ Treg together with the generation of both Foxp 3+ andFoxp3−CD25− CD4+ T Reg.
Journal ArticleDOI
Human Mucosa-Associated Invariant T Cells Accumulate in Colon Adenocarcinomas but Produce Reduced Amounts of IFN-γ.
Patrik Sundström,Filip Ahlmanner,Paulina Akeus,Malin Sundquist,Samuel Alsén,Ulf Yrlid,Lars Börjesson,Åsa Sjöling,Åsa Sjöling,Bengt Gustavsson,S. B. Justin Wong,Marianne Quiding-Järbrink +11 more
TL;DR: It is suggested that MAIT cells have the capacity to promote local immune responses to tumors, but factors in the tumor microenvironment act to reduce MAIT cell IFN-γ production.