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Lothar H. Wieler

Researcher at Robert Koch Institute

Publications -  272
Citations -  17664

Lothar H. Wieler is an academic researcher from Robert Koch Institute. The author has contributed to research in topics: Escherichia coli & Virulence. The author has an hindex of 62, co-authored 238 publications receiving 15200 citations. Previous affiliations of Lothar H. Wieler include Free University of Berlin & University of Giessen.

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Sex and virulence in Escherichia coli: an evolutionary perspective

TL;DR: The evolution of virulence is linked to bacterial sex because rates of evolution have accelerated in pathogenic lineages, culminating in highly virulent organisms whose genomic contents are altered frequently by increased rates of homologous recombination.
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Extended-spectrum β-lactamase-producing and AmpC-producing Escherichia coli from livestock and companion animals, and their putative impact on public health: a global perspective

TL;DR: The opinion that animal ESBL-producing E. coli is a major source of human infections is oversimplified, and neglects a highly complex scenario.
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Avian pathogenic, uropathogenic, and newborn meningitis-causing Escherichia coli: How closely related are they?

TL;DR: The hypothesis that poultry may be a vehicle or even a reservoir for human ExPEC strains and APEC potentially serve as a reservoir of virulence-associated genes for UPEC and NMEC is supported, and some ExPec strains, although of different pathotypes, may share common ancestors, and as a conclusion certain APEC subgroups have to be considered potential zoonotic agents.
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Characterization of a porcine intestinal epithelial cell line for in vitro studies of microbial pathogenesis in swine

TL;DR: The permanent porcine intestinal epithelial cell line, IPEC-J2, is characterized using a variety of methods to assess the usefulness of this cell line as an in vitro infection model and concludes that it provides a relevant in vitro model system for porCine intestinal pathogen–host cell interactions.