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Ascanio S. Maia
Researcher at Utrecht University
Publications - 5
Citations - 1427
Ascanio S. Maia is an academic researcher from Utrecht University. The author has contributed to research in topics: Synaptic vesicle & Neurotransmitter secretion. The author has an hindex of 5, co-authored 5 publications receiving 1340 citations. Previous affiliations of Ascanio S. Maia include University Medical Center Utrecht.
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Journal ArticleDOI
Synaptic Assembly of the Brain in the Absence of Neurotransmitter Secretion
Matthijs Verhage,Ascanio S. Maia,Jaap J. Plomp,Arjen B. Brussaard,J H Heeroma,H. Vermeer,Ruud F. Toonen,Robert E. Hammer,T K van den Berg,Markus Missler,Hans J. Geuze,Thomas C. Südhof +11 more
TL;DR: Synaptic connectivity does not depend on neurotransmitter secretion, but its maintenance does, and neurotransmitter secretion probably functions to validate already established synaptic connections.
Journal ArticleDOI
Quantification of synapse formation and maintenance in vivo in the absence of synaptic release.
Jildau Bouwman,Jildau Bouwman,Ascanio S. Maia,P.G. Camoletto,P.G. Camoletto,George Posthuma,Eric W. Roubos,Viola Oorschot,Judith Klumperman,Matthijs Verhage,Matthijs Verhage +10 more
TL;DR: Quantifying synapses and their morphology in the neocortical marginal zone of munc18-1 deficient mice suggest that secretion of neurotransmitters and neuromodulatory substances is required for synapse maintenance, not for synaptogenesis.
Journal ArticleDOI
The role of Munc18-1 in docking and exocytosis of peptide hormone vesicles in the anterior pituitary
Niki Korteweg,Ascanio S. Maia,Brenda Thompson,Eric W. Roubos,J. Peter H. Burbach,Matthijs Verhage,Matthijs Verhage +6 more
TL;DR: This work has shown that the presence of the soluble protein Munc18‐1 is essential for synaptic vesicle secretion in neurons, and its role in the secretion of classical transmitters and peptide transmitters from LDCVs is unclear.
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Sauvagine and TRH differentially stimulate proopiomelanocortin biosynthesis in the Xenopus laevis intermediate pituitary
TL;DR: The observations indicate that the neuropeptides sauvagine and TRH differently control POMC biosynthesis in the Xenopus intermediate pituitary, and this differential regulation is not only apparent with regard to time aspects.
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Development of the mouse hypothalamo-neurohypophysial system in the munc18-1 null mutant that lacks regulated secretion.
TL;DR: The results indicate that peptide gene expression, axon outgrowth and migration are intrinsic developmental events in these peptidergic neurons, that are initiated in the munc18–1 null mutant.