V
Viola Oorschot
Researcher at Utrecht University
Publications - 83
Citations - 11424
Viola Oorschot is an academic researcher from Utrecht University. The author has contributed to research in topics: Endosome & Golgi apparatus. The author has an hindex of 51, co-authored 80 publications receiving 10509 citations. Previous affiliations of Viola Oorschot include University of Queensland & Monash University, Clayton campus.
Papers
More filters
Journal ArticleDOI
Termination of autophagy and reformation of lysosomes regulated by mTOR
Li Yu,Christina K. McPhee,Christina K. McPhee,Lixin Zheng,Gonzalo A. Mardones,Gonzalo A. Mardones,Yueguang Rong,Junya Peng,Na Mi,Ying Zhao,Zhihua Liu,Fengyi Wan,Dale W. Hailey,Viola Oorschot,Judith Klumperman,Eric H. Baehrecke,Michael J. Lenardo +16 more
TL;DR: It is shown that mTOR signalling in rat kidney cells is inhibited during initiation of autophagy, but reactivated by prolonged starvation, and this generates proto-lysosomal tubules and vesicles that extrude from autolysosomes and ultimately mature into functional lysosomes, thereby restoring the full complement of lysosity in the cell.
Journal ArticleDOI
Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes.
Peter J. Peters,Jannie Borst,Viola Oorschot,M Fukuda,O Krähenbühl,J Tschopp,Jan W. Slot,Hans J. Geuze +7 more
TL;DR: In this article, the subcellular localization of perforin, granzymes, and known endosomal and lysosomal marker proteins was determined in human and murine CTL, by immunogold labeling of ultrathin cryosections followed by electron microscopy.
Journal ArticleDOI
Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments.
TL;DR: The intracellular distribution of MHC class I and class II molecules reflects the dichotomy in presentation of antigen from endogenous and exogenous origin, respectively.
Journal ArticleDOI
PTRF-Cavin, a Conserved Cytoplasmic Protein Required for Caveola Formation and Function
Michelle M. Hill,Michele Bastiani,Robert Luetterforst,Matthew Kirkham,Annika Kirkham,Susan J. Nixon,Piers J. Walser,Daniel Abankwa,Viola Oorschot,Sally Martin,John F. Hancock,Robert G. Parton +11 more
TL;DR: It is concluded that PTRF-Cavin is required for caveola formation and sequestration of mobile caveolin into immobile caveolae.
Journal ArticleDOI
Sorting Nexin-1 Mediates Tubular Endosome-to-TGN Transport through Coincidence Sensing of High- Curvature Membranes and 3-Phosphoinositides
Jez G. Carlton,Miriam V. Bujny,Brian J. Peter,Viola Oorschot,Anna C. Rutherford,Harry Mellor,Judith Klumperman,Harvey T. McMahon,Peter J. Cullen +8 more
TL;DR: The data support an evolutionarily conserved function for SNX1 from yeast to mammals and provide functional insight into the molecular mechanisms underlying lipid-mediated protein targeting and tubular-based protein sorting.