M
Matthijs Verhage
Researcher at VU University Amsterdam
Publications - 213
Citations - 15026
Matthijs Verhage is an academic researcher from VU University Amsterdam. The author has contributed to research in topics: Synaptic vesicle & Exocytosis. The author has an hindex of 56, co-authored 192 publications receiving 12488 citations. Previous affiliations of Matthijs Verhage include Utrecht University & University of Amsterdam.
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Journal ArticleDOI
Genome-wide association analysis identifies 13 new risk loci for schizophrenia
Stephan Ripke,Stephan Ripke,Colm O'Dushlaine,Kimberly Chambert,Jennifer L. Moran,Anna K. Kähler,Anna K. Kähler,Anna K. Kähler,Susanne Akterin,Sarah E. Bergen,Ann L. Collins,James J. Crowley,Menachem Fromer,Menachem Fromer,Menachem Fromer,Yunjung Kim,Sang Hong Lee,Patrik K. E. Magnusson,Nicholas E. Sanchez,Eli A. Stahl,Stephanie Williams,Naomi R. Wray,Kai Xia,F Bettella,Anders D. Børglum,Anders D. Børglum,Anders D. Børglum,Brendan Bulik-Sullivan,Paul Cormican,Nicholas John Craddock,Christiaan de Leeuw,Christiaan de Leeuw,Naser Durmishi,Michael Gill,Vera Golimbet,Marian L. Hamshere,Peter Holmans,David M. Hougaard,Kenneth S. Kendler,Kuang Fei Lin,Derek W. Morris,Ole Mors,Ole Mors,Preben Bo Mortensen,Preben Bo Mortensen,Benjamin M. Neale,Benjamin M. Neale,Francis A. O'Neill,Michael John Owen,MilicaPejovic Milovancevic,Danielle Posthuma,Danielle Posthuma,John Powell,Alexander Richards,Brien P. Riley,Douglas M. Ruderfer,Dan Rujescu,Dan Rujescu,Engilbert Sigurdsson,Teimuraz Silagadze,August B. Smit,Hreinn Stefansson,Stacy Steinberg,Jaana Suvisaari,Sarah Tosato,Matthijs Verhage,James T.R. Walters,Elvira Bramon,Elvira Bramon,Aiden Corvin,Michael Conlon O'Donovan,Kari Stefansson,Edward M. Scolnick,Shaun Purcell,Steve McCarroll,Steve McCarroll,Pamela Sklar,Christina M. Hultman,Patrick F. Sullivan,Patrick F. Sullivan +79 more
TL;DR: The authors conducted a multi-stage genome-wide association study (GWAS) for schizophrenia and found that 8,300 independent, mostly common SNPs (95% credible interval of 6,300-10,200 SNPs) contribute to risk for schizophrenia.
Journal ArticleDOI
Synaptic Assembly of the Brain in the Absence of Neurotransmitter Secretion
Matthijs Verhage,Ascanio S. Maia,Jaap J. Plomp,Arjen B. Brussaard,J H Heeroma,H. Vermeer,Ruud F. Toonen,Robert E. Hammer,T K van den Berg,Markus Missler,Hans J. Geuze,Thomas C. Südhof +11 more
TL;DR: Synaptic connectivity does not depend on neurotransmitter secretion, but its maintenance does, and neurotransmitter secretion probably functions to validate already established synaptic connections.
Journal ArticleDOI
Mapping genomic loci implicates genes and synaptic biology in schizophrenia
Vassily Trubetskoy,Antonio F. Pardiñas,Ting Qi,Georgia Panagiotaropoulou,Swapnil Awasthi,Tim B. Bigdeli,Julien Bryois,Chia-Yen Chen,Charlotte Dennison,Lynsey S. Hall,Max Lam,Kyoko Watanabe,Oleksandr Frei,Tian Ge,Janet C Harwood,Frank Koopmans,Sigurdur Magnusson,Alexander Richards,Julia Sidorenko,Yang Wu,Jian Zeng,Jakob Grove,Minsoo Kim,Zhiqiang Li,Georgios Voloudakis,Wen Jie Zhang,Mark Adams,Ingrid Agartz,Elizabeth G. Atkinson,Esben Agerbo,Mariam M. Al Eissa,Margot Albus,Madeline Alexander,Behrooz Z. Alizadeh,Köksal Alptekin,Thomas Damm Als,Farooq Amin,Volker Arolt,Manuel Arrojo,Lavinia Athanasiu,M. Helena Azevedo,Silviu Alin Bacanu,Nicholas Bass,Martin Begemann,Richard A. Belliveau,Judit Bene,Beben Benyamin,Sarah E. Bergen,Giuseppe Blasi,Julio Bobes,Stefano Bonassi,Alice Braun,Rodrigo A. Bressan,Evelyn J. Bromet,Richard Bruggeman,Peter J. Buckley,Randy L. Buckner,Jonas Bybjerg-Grauholm,Wiepke Cahn,Murray J. Cairns,Monica E. Calkins,Vaughan J. Carr,David J. Castle,Stanley V. Catts,Kimberly Chambert,Raymond C.K. Chan,Boris Chaumette,Wei Cheng,Eric F.C. Cheung,Siow Ann Chong,David Cohen,Angèle Consoli,Quirino Cordeiro,Javier Costas,Charles Curtis,Michael H. Davidson,Kenneth L. Davis,Lieuwe de Haan,Franziska Degenhardt,Lynn E. DeLisi,Ditte Demontis,Faith Dickerson,Dimitris Dikeos,Timothy G. Dinan,Srdjan Djurovic,Jubao Duan,Giuseppe Ducci,Frank Dudbridge,Johan G. Eriksson,Lourdes Fañanás,Stephen V. Faraone,Alessia Fiorentino,Andreas J. Forstner,Josef Frank,Nelson B. Freimer,Menachem Fromer,Alessandra Frustaci,Ary Gadelha,Giulio Genovese,Elliot S. Gershon,Marianna Giannitelli,Ina Giegling,Paola Giusti-Rodríguez,Stephanie Godard,Jackie Goldstein,Javier González Peñas,Ana González-Pinto,Srihari Gopal,Jacob Gratten,Michael F. Green,Tiffany A. Greenwood,Olivier Guillin,Sinan Gülöksüz,Raquel E. Gur,Ruben C. Gur,Blanca Gutiérrez,Eric Hahn,Hakon Hakonarson,Vahram Haroutunian,T. Hartmann,Carol Harvey,Caroline Hayward,Frans Henskens,Stefan Herms,Per Hoffmann,Daniel P. Howrigan,Masashi Ikeda,Conrad Iyegbe,Inge Joa,Antonio Julià,Anna K. Kähler,Tony Kam-Thong,Yoichiro Kamatani,Sena Karachanak-Yankova,Oussama Kebir,Matthew C. Keller,Brian Kelly,Andrey Khrunin,Sung-Wan Kim,Janis Klovins,N. V. Kondratiev,Bettina Konte,Julia Kraft,Michiaki Kubo,Vaidutis Kučinskas,Zita Ausrele Kucinskiene,Agung A.A.A Kusumawardhani,Hana Kuzelova-Ptackova,Stefano Landi,Laura C. Lazzeroni,Phil Lee,Sophie E. Legge,Douglas S. Lehrer,Rebekka Lencer,Bernard Lerer,Miaoxin Li,Jeffrey A. Lieberman,Gregory A. Light,Svetlana A. Limborska,Chih-Min Liu,Jouko Lönnqvist,Carmel M. Loughland,Jan Lubinski,Jurjen J. Luykx,Amy Lynham,Milan Macek,Andrew Mackinnon,Patrik K. E. Magnusson,Brion S. Maher,Wolfgang Mader,Dolores Malaspina,Jacques Mallet,Stephen R. Marder,Sara Marsal,Alicia R. Martin,Lourdes Martorell,Manuel Mattheisen,Robert W. McCarley,Colm McDonald,John J. McGrath,Helena Medeiros,Sandra Meier,Béla Melegh,Ingrid Melle,Raquelle I. Mesholam-Gately,Andres Metspalu,Patricia T. Michie,Lili Milani,Vihra Milanova,Marina Mitjans,Espen Molden,Esther Molina,María Dolores Moltó,Valeria Mondelli,Carmen Moreno,Christopher P. Morley,Gerard Muntané,Kieran C. Murphy,Inez Myin-Germeys,Igor Nenadic,Gerald Nestadt,Liene Nikitina-Zake,Cristiano Noto,Keith H. Nuechterlein,Niamh L. O'Brien,F. Anthony O'Neill,Sang Oh,Ann Olincy,Vanessa Kiyomi Ota,Christos Pantelis,George N. Papadimitriou,Mara Parellada,Tiina Paunio,Renata Pellegrino,Sathish Periyasamy,Diana O. Perkins,Bruno Pfuhlmann,Olli Pietiläinen,Jonathan Pimm,David J. Porteous,John Powell,Diego Quattrone,Digby Quested,Allen D. Radant,Antonio Rampino,Mark Hyman Rapaport,Anna Rautanen,Abraham Reichenberg,Cheryl A. Roe,Joshua L. Roffman,Julian Roth,Matthias Rothmund,Bart P. F. Rutten,Safaa Saker-Delye,Veikko Salomaa,Julio Sanjuán,Marcos L. Santoro,Adam Savitz,Ulrich Schall,Rodney J. Scott,Larry J. Seidman,Sally I. Sharp,Jianxin Shi,Larry J. Siever,Engilbert Sigurdsson,Kang Sim,Nora Skarabis,Petr Slominsky,Hon-Cheong So,Janet L. Sobell,Erik Söderman,Helen J. Stain,Nils Eiel Steen,Agnes A. Steixner-Kumar,Elisabeth Stögmann,William S. Stone,Richard E. Straub,Fabian Streit,Eric Strengman,T. Scott Stroup,Mythily Subramaniam,Catherine A. Sugar,Jaana Suvisaari,Dragan M. Svrakic,Neal R. Swerdlow,Jin P. Szatkiewicz,Thi Minh Tam Ta,Atsushi Takahashi,Chikashi Terao,Florence Thibaut,Draga Toncheva,Paul A. Tooney,Silvia Torretta,Sarah Tosato,G.B. Tura,Bruce I. Turetsky,Alp Üçok,Arne E. Vaaler,Therese van Amelsvoort,Ruud van Winkel,Juha Veijola,John L. Waddington,Henrik Walter,Anna Waterreus,Bradley T. Webb,Mark Weiser,Nigel Williams,Stephanie H. Witt,Brandon Wormley,Jing Qin Wu,Zhida Xu,R.T Yolken,Clement C. Zai,Wei Zhou,Feng Zhu,Fritz Zimprich,E. Cem Atbasoglu,Muhammad Ayub,Christian Benner,Alessandro Bertolini,Donald W. Black,Nicholas John Bray,Gerome Breen,Nancy G. Buccola,William Byerley,Wei J. Chen,C. Robert Cloninger,Benedicto Crespo-Facorro,Gary Donohoe,Robert Freedman,Cherrie Galletly,Michael J. Gandal,Massimo Gennarelli,David M. Hougaard,Hai-Gwo Hwu,Assen Jablensky,Steven A. McCarroll,Jennifer L. Moran,Ole Mors,Preben Bo Mortensen,Bertram Müller-Myhsok,Amanda L. Neil,Merete Nordentoft,Michele T. Pato,Tracey L. Petryshen,Matti Pirinen,Ann E. Pulver,Thomas G. Schulze,Jeremy M. Silverman,Jordan W. Smoller,Eli A. Stahl,Debby W. Tsuang,Elisabet Vilella,Shi‐Heng Wang,Shuhua Xu,Rolf Adolfsson,Celso Arango,Bernhard T. Baune,Sintia Iole Belangero,Anders D. Børglum,David L. Braff,Elvira Bramon,Joseph D. Buxbaum,Dominique Campion,Jorge A. Cervilla,Sven Cichon,David A. Collier,Aiden Corvin,David Curtis,Marta Di Forti,Enrico Domenici,Hannelore Ehrenreich,Valentina Escott-Price,Tõnu Esko,Ayman H. Fanous,A. E. Gareeva,Micha Gawlik,Pablo V. Gejman,Michael Gill,Stephen J. Glatt,Vera Golimbet,Kyung Sue Hong,Christina M. Hultman,Steven E. Hyman,Nakao Iwata,Erik G. Jönsson,René S. Kahn,James L. Kennedy,Elza Khusnutdinova,George Kirov,James A. Knowles,Marie-Odile Krebs,Claudine Laurent-Levinson,Jimmy Lee,Todd Lencz,Douglas F. Levinson,Qingqin S. Li,Jianjun Liu,Anil K. Malhotra,Dheeraj Malhotra,Andrew M. McIntosh,Andrew McQuillin,Paulo Rossi Menezes,Vera A. Morgan,Derek W. Morris,Bryan J. Mowry,Robin M. Murray,Vishwajit L. Nimgaonkar,Markus M. Nöthen,Roel A. Ophoff,Sara A. Paciga,Aarno Palotie,Carlos N. Pato,Shengying Qin,Marcella Rietschel,Brien P. Riley,Margarita Rivera,Dan Rujescu,Meram Can Saka,Alan R. Sanders,Sibylle G. Schwab,Alessandro Serretti,Pak C. Sham,Yongyong Shi,David St Clair,Hreinn Stefansson,Kari Stefansson,Ming T. Tsuang,Jim van Os,Marquis P. Vawter,Daniel R. Weinberger,Thomas Werge,Dieter B. Wildenauer,Xin-ming Yu,Weihua Yue,Peter Holmans,Andrew Pocklington,Panos Roussos,Evangelos Vassos,Matthijs Verhage,Peter M. Visscher,Danielle Posthuma,Ole A. Andreassen,Kenneth S. Kendler,Michael John Owen,Naomi R. Wray,Mark J. Daly,Hailiang Huang,Benjamin M. Neale,Patrick F. Sullivan,Stephan Ripke,James T.R. Walters,Michael Conlon O'Donovan +432 more
TL;DR: In this article , a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals was conducted, and the authors reported common variant associations at 287 distinct genomic loci.
Journal ArticleDOI
A solution to dependency: using multilevel analysis to accommodate nested data
TL;DR: The factors affecting the type I error rate and the statistical power in nested data, methods that accommodate dependency between observations and ways to determine the optimal study design when data are nested are discussed.
Journal ArticleDOI
SynGO : An Evidence-Based, Expert-Curated Knowledge Base for the Synapse
Frank Koopmans,Pim van Nierop,Maria Andres-Alonso,Andrea Byrnes,Tony Cijsouw,Marcelo P. Coba,L. Niels Cornelisse,Ryan J. Farrell,Hana L. Goldschmidt,Daniel P. Howrigan,Natasha K. Hussain,Natasha K. Hussain,Cordelia Imig,Arthur P.H. de Jong,Hwajin Jung,Mahdokht Kohansal-Nodehi,Barbara Kramarz,Noa Lipstein,Ruth C. Lovering,Harold D. MacGillavry,Vittoria Mariano,Vittoria Mariano,Huaiyu Mi,Momchil Ninov,David Osumi-Sutherland,Rainer Pielot,Karl-Heinz Smalla,Haiming Tang,Katherine Tashman,Ruud F. Toonen,Chiara Verpelli,Rita Reig-Viader,Kyoko Watanabe,Jan R.T. van Weering,Tilmann Achsel,Tilmann Achsel,Ghazaleh Ashrafi,Nimra Asi,Tyler C. Brown,Pietro De Camilli,Marc Feuermann,Rebecca E. Foulger,Pascale Gaudet,Anoushka Joglekar,Alexandros K. Kanellopoulos,Alexandros K. Kanellopoulos,Robert C. Malenka,Roger A. Nicoll,Camila Pulido,Jaime de Juan-Sanz,Morgan Sheng,Thomas C. Südhof,Hagen Tilgner,Claudia Bagni,Claudia Bagni,Àlex Bayés,Thomas Biederer,Nils Brose,John Jia En Chua,Daniela C. Dieterich,Eckart D. Gundelfinger,Casper C. Hoogenraad,Richard L. Huganir,Richard L. Huganir,Reinhard Jahn,Pascal S. Kaeser,Eunjoon Kim,Michael R. Kreutz,Peter S. McPherson,Neale Bm,Vincent O'Connor,Danielle Posthuma,Timothy A. Ryan,Carlo Sala,Guoping Feng,Steven E. Hyman,Paul Thomas,August B. Smit,Matthijs Verhage +78 more
TL;DR: It is shown that synaptic genes are exceptionally well conserved and less tolerant to mutations than other genes, and among de novo variants associated with neurodevelopmental disorders, including schizophrenia.