B. Mark Evers

TL;DR: It is found that Snail is stabilized by the inflammatory cytokine TNFalpha through the activation of the NF-kappaB pathway, which is required for the induction of COP9 signalosome 2 (CSN2), which blocks the ubiquitination and degradation of Snail.

TL;DR: This study indicates that the loss of FBP1 is a critical oncogenic event in EMT and BLBC.

TL;DR: It is found that increased expression of mTOR, Raptor, and Rictor mRNA was noted with advanced stages of CRC, suggesting that mTOR signaling may be associated with CRC progression and metastasis, and provides the rationale for including mTOR kinase inhibitors, which inhibit both mTORC1 and m TORC2, as part of the therapeutic regimen for CRC patients.

TL;DR: Methylation of histone H3 on lysine 9 (H3K9me2) is critical for promoter DNA methylation of E-cadherin in three TGF-β-induced EMT model cell lines, as well as in CLBC cell Lines, revealing a critical mechanism underlying the epigenetic regulation of EMT.

TL;DR: It is suggested that the decreased activity of FKHRL1 and FKHR in prostate cancers resulting from loss of PTEN leads to a decrease in TRAIL expression that may contribute to increased survival of the tumor cells.