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Astrid Müller
Researcher at Center of Advanced European Studies and Research
Publications - 11
Citations - 662
Astrid Müller is an academic researcher from Center of Advanced European Studies and Research. The author has contributed to research in topics: Sperm & Hyperpolarization (biology). The author has an hindex of 8, co-authored 11 publications receiving 562 citations.
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Journal ArticleDOI
The CatSper channel: a polymodal chemosensor in human sperm
Christoph Brenker,Normann Goodwin,Ingo Weyand,Nachiket D. Kashikar,M. Naruse,M. Krahling,Astrid Müller,Ulrich Benjamin Kaupp,Timo Strünker +8 more
TL;DR: The results contest current concepts of Ca2+ signalling by GPCR and cAMP in mammalian sperm: ligands thought to activate metabotropic pathways, in fact, act via a common ionotropic mechanism.
Journal ArticleDOI
Direct action of endocrine disrupting chemicals on human sperm
Christian Schiffer,Astrid Müller,Dorte L Egeberg,Luis Alvarez,Christoph Brenker,Anders Rehfeld,Hanne Frederiksen,Benjamin Wäschle,U. Benjamin Kaupp,Melanie Balbach,Dagmar Wachten,Niels E. Skakkebæk,Kristian Almstrup,Timo Strünker +13 more
TL;DR: It is concluded that EDCs interfere with various sperm functions and, thereby, might impair human fertilization.
Journal ArticleDOI
The CatSper channel controls chemosensation in sea urchin sperm
Reinhard Seifert,Reinhard Seifert,Melanie Flick,Wolfgang Bönigk,Luis Alvarez,Christian Trötschel,Ansgar Poetsch,Astrid Müller,Normann Goodwin,Normann Goodwin,Patric Pelzer,Patric Pelzer,Nachiket D. Kashikar,Nachiket D. Kashikar,Elisabeth Kremmer,Jan F. Jikeli,Bernd Timmermann,Heiner Kuhl,Dmitry Fridman,Dmitry Fridman,Florian Windler,Florian Windler,U. Benjamin Kaupp,U. Benjamin Kaupp,Timo Strünker,Timo Strünker +25 more
TL;DR: CatSper mediates the chemoattractant‐evoked Ca2+ influx and controls chemotactic steering and a concomitant alkalization serves as a highly cooperative mechanism that enables CatSper to transduce periodic voltage changes into Ca2- bursts.
Journal ArticleDOI
The Ca2+-activated K+ current of human sperm is mediated by Slo3
Christoph Brenker,Yu Zhou,Astrid Müller,Fabio Andres Echeverry,Christian Trötschel,Ansgar Poetsch,Xiao-Ming Xia,Wolfgang Bönigk,Christopher J. Lingle,U. Benjamin Kaupp,Timo Strünker +10 more
TL;DR: It is proposed that the progesterone-evoked Ca2+ influx carried by voltage-gated CatSper channels is limited by Ca2-controlled hyperpolarization via Slo3, which represents the principal K+ channel in human sperm that carries the Ca1+-activated IKSper current.
Journal ArticleDOI
A K+-selective CNG channel orchestrates Ca2+ signalling in zebrafish sperm
Sylvia Fechner,Luis Alvarez,Wolfgang Bönigk,Astrid Müller,Thomas K. Berger,René Pascal,Christian Trötschel,Ansgar Poetsch,Gabriel Stölting,Kellee R. Siegfried,Elisabeth Kremmer,Reinhard Seifert,U. Benjamin Kaupp +12 more
TL;DR: This work identifies in sperm of the freshwater fish Danio rerio a novel CNGK family member featuring non-canonical properties located in the sperm head rather than the flagellum and is controlled by intracellular pH, but not cyclic nucleotides.