H
Heiner Kuhl
Researcher at Leibniz Association
Publications - 71
Citations - 4762
Heiner Kuhl is an academic researcher from Leibniz Association. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 26, co-authored 67 publications receiving 4028 citations. Previous affiliations of Heiner Kuhl include Max Planck Society.
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Journal ArticleDOI
The genome sequence of Atlantic cod reveals a unique immune system
Bastiaan Star,Alexander J. Nederbragt,Sissel Jentoft,Unni Grimholt,Martin Malmstrøm,Tone F. Gregers,Trine B. Rounge,Jonas Paulsen,Jonas Paulsen,Monica Hongrø Solbakken,Animesh Sharma,Ola F. Wetten,Ola F. Wetten,Anders Lanzén,Roger Winer,James D.R. Knight,Jan-Hinnerk Vogel,Bronwen Aken,Øivind Andersen,Karin Lagesen,Ave Tooming-Klunderud,Rolf B. Edvardsen,Kirubakaran G. Tina,Kirubakaran G. Tina,Mari Espelund,Chirag Nepal,Christopher Previti,Bård Ove Karlsen,Truls Moum,Morten Skage,Paul R. Berg,Tor Gjøen,Heiner Kuhl,Jim Thorsen,Ketil Malde,Richard Reinhardt,Lei Du,Steinar Johansen,Steinar Johansen,Steve Searle,Sigbjørn Lien,Frank Nilsen,Inge Jonassen,Stig W. Omholt,Stig W. Omholt,Nils Christian Stenseth,Kjetill S. Jakobsen +46 more
TL;DR: The genome sequence of Atlantic cod is presented, showing evidence for complex thermal adaptations in its haemoglobin gene cluster and an unusual immune architecture compared to other sequenced vertebrates.
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European sea bass genome and its variation provide insights into adaptation to euryhalinity and speciation
Mbaye Tine,Heiner Kuhl,Pierre-Alexandre Gagnaire,Bruno Louro,Erick Desmarais,Rute S.T. Martins,Jochen Hecht,Florian Knaust,Khalid Belkhir,Sven Klages,Roland Dieterich,Kurt Stueber,Francesc Piferrer,Bruno Guinand,Nicolas Bierne,Filip Volckaert,Luca Bargelloni,Deborah M. Power,François Bonhomme,François Bonhomme,Adelino V.M. Canario,Richard Reinhardt +21 more
TL;DR: Comparing predictions of alternative demographic models to the joint allele-frequency spectrum indicates that genomic islands of differentiation between sea bass lineages were generated by varying rates of introgression across the genome following a period of geographical isolation.
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Whole genome analysis of the marine Bacteroidetes‘Gramella forsetii’ reveals adaptations to degradation of polymeric organic matter
Margarete Bauer,Michael Kube,Hanno Teeling,Michael Richter,Thierry Lombardot,Elke Allers,Chris Würdemann,Christian Quast,Heiner Kuhl,Florian Knaust,Dagmar Woebken,Kerstin Bischof,Marc Mussmann,Jomuna V. Choudhuri,Folker Meyer,Richard Reinhardt,Rudolf Amann,Frank Oliver Glöckner,Frank Oliver Glöckner +18 more
TL;DR: Functional analysis of the predicted proteome disclosed several traits which in joint consideration suggest a clear adaptation of this marine Bacteroidetes representative to the degradation of high molecular weight organic matter, such as a substantial suite of genes encoding hydrolytic enzymes, a predicted preference for polymeric carbon sources and a distinct capability for surface adhesion.
Journal ArticleDOI
Genome sequence of the chlorinated compound–respiring bacterium Dehalococcoides species strain CBDB1
TL;DR: Comparison with the recently sequenced genome of Dehalococcoides ethenogenes strain 195 reveals a high degree of gene context conservation but exceptionally high plasticity in all regions containing rdh genes, suggesting that these regions are under intense evolutionary pressure.
Journal ArticleDOI
DNAH5 Mutations Are a Common Cause of Primary Ciliary Dyskinesia with Outer Dynein Arm Defects
Nada Hornef,Heike Olbrich,Judit Horvath,Maimoona B Zariwala,Manfred Fliegauf,Niki T. Loges,Johannes H. Wildhaber,Peadar G. Noone,Marcus P. Kennedy,Stylianos E. Antonarakis,Jean-Louis Blouin,Lucia Bartoloni,Thomas Nüsslein,Peter Ahrens,Matthias Griese,Heiner Kuhl,Ralf Sudbrak,Michael R. Knowles,Richard Reinhardt,Heymut Omran +19 more
TL;DR: DNAH5 is frequently mutated in patients with PCD exhibiting outer dynein arm defects and mutations cluster in five exons.