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Nachiket D. Kashikar
Researcher at Janssen Pharmaceutica
Publications - 18
Citations - 1051
Nachiket D. Kashikar is an academic researcher from Janssen Pharmaceutica. The author has contributed to research in topics: Sperm chemotaxis & Sperm. The author has an hindex of 12, co-authored 16 publications receiving 969 citations. Previous affiliations of Nachiket D. Kashikar include University of Mumbai & Marine Biological Laboratory.
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Journal ArticleDOI
Mechanisms of Sperm Chemotaxis
TL;DR: This review raises new questions and discusses current concepts of sperm chemotaxis, and highlights commonalities and differences of sensory signaling in sperm, photoreceptors, and olfactory neurons.
Journal ArticleDOI
The CatSper channel: a polymodal chemosensor in human sperm
Christoph Brenker,Normann Goodwin,Ingo Weyand,Nachiket D. Kashikar,M. Naruse,M. Krahling,Astrid Müller,Ulrich Benjamin Kaupp,Timo Strünker +8 more
TL;DR: The results contest current concepts of Ca2+ signalling by GPCR and cAMP in mammalian sperm: ligands thought to activate metabotropic pathways, in fact, act via a common ionotropic mechanism.
Journal ArticleDOI
A K+-selective cGMP-gated ion channel controls chemosensation of sperm
Timo Strünker,Ingo Weyand,Ingo Weyand,Wolfgang Bönigk,Qui Van,Astrid Loogen,Joel E Brown,Nachiket D. Kashikar,Volker Hagen,Eberhard Krause,U. Benjamin Kaupp,U. Benjamin Kaupp +11 more
TL;DR: A model of chemosensory transduction in sperm is established whereby a cGMP-induced hyperpolarization opens Cav channels by a 'recovery-from-inactivation' mechanism and an evolutionary kinship between transduction mechanisms in sperm and photoreceptors is unveiled.
Journal ArticleDOI
The rate of change in Ca2+ concentration controls sperm chemotaxis
Luis Alvarez,Luru Dai,Benjamin M. Friedrich,Nachiket D. Kashikar,Ingo Gregor,René Pascal,U. Benjamin Kaupp +6 more
TL;DR: In this article, the authors proposed a cellular mechanism for a chemical differentiator that computes a time derivative for the changes in intracellular Ca(2+) concentration and path curvature.
Journal ArticleDOI
The CatSper channel controls chemosensation in sea urchin sperm
Reinhard Seifert,Reinhard Seifert,Melanie Flick,Wolfgang Bönigk,Luis Alvarez,Christian Trötschel,Ansgar Poetsch,Astrid Müller,Normann Goodwin,Normann Goodwin,Patric Pelzer,Patric Pelzer,Nachiket D. Kashikar,Nachiket D. Kashikar,Elisabeth Kremmer,Jan F. Jikeli,Bernd Timmermann,Heiner Kuhl,Dmitry Fridman,Dmitry Fridman,Florian Windler,Florian Windler,U. Benjamin Kaupp,U. Benjamin Kaupp,Timo Strünker,Timo Strünker +25 more
TL;DR: CatSper mediates the chemoattractant‐evoked Ca2+ influx and controls chemotactic steering and a concomitant alkalization serves as a highly cooperative mechanism that enables CatSper to transduce periodic voltage changes into Ca2- bursts.