A
Astrid Nehlig
Researcher at Necker-Enfants Malades Hospital
Publications - 12
Citations - 2885
Astrid Nehlig is an academic researcher from Necker-Enfants Malades Hospital. The author has contributed to research in topics: Epilepsy & Caffeine. The author has an hindex of 7, co-authored 12 publications receiving 2581 citations. Previous affiliations of Astrid Nehlig include French Institute of Health and Medical Research & University of Paris.
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Journal Article
Actions of Caffeine in the Brain with Special Reference to Factors That Contribute to Its Widespread Use
TL;DR: Caffeine is the most widely consumed behaviorally active substance in the world and almost all caffeine comes from dietary sources (beverages and food).
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Interindividual Differences in Caffeine Metabolism and Factors Driving Caffeine Consumption
TL;DR: A better picture is reached on how a multiplicity of biologic mechanisms seems to drive the levels of caffeine consumption, although much more knowledge is still required to understand caffeine consumption and effects on body functions.
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Issues related to development of antiepileptogenic therapies.
Asla Pitkänen,Astrid Nehlig,Amy R. Brooks-Kayal,F. Edward Dudek,Daniel Friedman,Aristea S. Galanopoulou,Frances E. Jensen,Rafal M. Kaminski,Jaideep Kapur,Henrik Klitgaard,Wolfgang Löscher,Istvan Mody,Dieter Schmidt +12 more
TL;DR: This article provides recommendations on how to design a preclinical AEG monotherapy trial in adult animals and addresses study design, animal and model selection, number of studies needed, issues related to administration of the treatment, outcome measures, statistics, and reporting.
Journal ArticleDOI
Epilepsy therapy development: technical and methodologic issues in studies with animal models.
Aristea S. Galanopoulou,Merab Kokaia,Jeffrey A. Loeb,Astrid Nehlig,Asla Pitkänen,Michael A. Rogawski,Kevin J. Staley,Vicky Whittemore,F. Edward Dudek +8 more
TL;DR: Methods and reporting practices that will enhance the uniformity, reliability, and reporting of early stage preclinical studies with animal seizure and epilepsy models that aim to develop and evaluate new therapies for seizures or epilepsies, using multidisciplinary approaches are proposed.
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A companion to the preclinical common data elements on neurobehavioral comorbidities of epilepsy: a report of the TASK3 behavior working group of the ILAE/AES Joint Translational Task Force
Andrey Mazarati,Nigel C. Jones,Aristea S. Galanopoulou,Lauren C. Harte-Hargrove,Lisa E. Kalynchuk,Pierre-Pascal Lenck-Santini,Pierre-Pascal Lenck-Santini,Jesús-Servando Medel-Matus,Astrid Nehlig,Liset Menendez de la Prida,Karine Sarkisova,Jana Velíšková +11 more
TL;DR: This companion describes the different types of assessments, and highlights the importance of rigorous data collection and transparency in this regard, and represents, to the authors' knowledge, the first such resource dedicated to preclinical CDEs for behavioral testing of rodents.