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Astrid Sasse
Researcher at Trinity College, Dublin
Publications - 37
Citations - 1036
Astrid Sasse is an academic researcher from Trinity College, Dublin. The author has contributed to research in topics: Histamine & Histamine H3 receptor. The author has an hindex of 17, co-authored 35 publications receiving 862 citations. Previous affiliations of Astrid Sasse include Max Planck Society & Dublin City University.
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Journal ArticleDOI
Activation of TRPV1 mediates calcitonin gene-related peptide release, which excites trigeminal sensory neurons and is attenuated by a retargeted botulinum toxin with anti-nociceptive potential.
Jianghui Meng,Saak V. Ovsepian,Jiafu Wang,Mark Pickering,Astrid Sasse,K. R. Aoki,Gary W. Lawrence,James Oliver Dolly +7 more
TL;DR: The basal release of proinflammatory calcitonin gene-related peptide was shown to increase the excitability of trigeminal sensory neurons in brainstem slices via C GRP1 receptors because the effect was negated by an antagonist, CGRP8–37.
Journal ArticleDOI
Current Enlightenment About Etiology and Pharmacological Treatment of Autism Spectrum Disorder.
TL;DR: The diversity of numerous aetiological factors and the alterations in variety of neurotransmitter generation, release and function linked to ASD are discussed with focus on drugs currently used to manage neuropsychiatric symptoms related to ASD.
Journal ArticleDOI
Novel Chimeras of Botulinum Neurotoxins A and E Unveil Contributions from the Binding, Translocation, and Protease Domains to Their Functional Characteristics
Jiafu Wang,Jianghui Meng,Gary W. Lawrence,Tomas H. Zurawski,Astrid Sasse,MacDara Bodeker,Marcella A. Gilmore,Ester Fernandez-Salas,Joseph Francis,Lance E. Steward,K. Roger Aoki,J. Oliver Dolly +11 more
TL;DR: Proof of principle is provided for tailoring the pharmacological properties of these toxins by protein engineering.
Journal ArticleDOI
Cortagine, a specific agonist of corticotropin-releasing factor receptor subtype 1, is anxiogenic and antidepressive in the mouse model.
TL;DR: Cortagine combines anxiogenic properties with antidepressive effects in the FST, and was more selective than oCRF, frequently used as CRF(1)-specific agonist, in stimulating the transfected cells to release cAMP.
Journal ArticleDOI
The rat H3 receptor: gene organization and multiple isoforms.
S. Morisset,Astrid Sasse,Florence Gbahou,Anne Héron,Xavier Ligneau,J. Tardivel-Lacombe,J C Schwartz,Jean-Michel Arrang +7 more
TL;DR: Two short variants are identified, which correspond to frame shift and stop codon interposition, respectively, and are presumably nonfunctional, among which H3(nf2) displays brain expression similar to that of the longer isoforms.