S
S. Morisset
Researcher at French Institute of Health and Medical Research
Publications - 28
Citations - 2106
S. Morisset is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Histamine H3 receptor & Receptor. The author has an hindex of 20, co-authored 28 publications receiving 2036 citations.
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Journal ArticleDOI
High constitutive activity of native H3 receptors regulates histamine neurons in brain.
S. Morisset,A. Rouleau,Xavier Ligneau,Florence Gbahou,J. Tardivel-Lacombe,Holger Stark,Schunack Walter G,Charon Robin Ganellin,J C Schwartz,J.M. Arrang +9 more
TL;DR: It is shown that constitutive activity of native H3 receptors is present in rodent brain and that it controls histaminergic neuron activity in vivo, and inverse agonists may find therapeutic applications, even in the case of diseases involving non-mutated receptors expressed at normal levels.
Journal ArticleDOI
Loss of constitutive activity of the growth hormone secretagogue receptor in familial short stature
Jacques Pantel,Marie Legendre,Sylvie Cabrol,Latifa Hilal,Yassir Hajaji,S. Morisset,Sylvie Nivot,Marie-Pierre Vie-Luton,Dominique Grouselle,Marc de Kerdanet,Abdelkrim Kadiri,Jacques Epelbaum,Yves Le Bouc,Serge Amselem +13 more
TL;DR: This mutation, which results in decreased cell-surface expression of the receptor, selectively impairs the constitutive activity of the GHSR, while preserving its ability to respond to ghrelin.
Journal ArticleDOI
Distinct pharmacology of rat and human histamine H3 receptors: role of two amino acids in the third transmembrane domain
Xavier Ligneau,S. Morisset,J. Tardivel-Lacombe,Florence Gbahou,Charon Robin Ganellin,Holger Stark,Walter Schunack,J.-C. Schwartz,J.M. Arrang +8 more
TL;DR: Starting from the sequence of the human histamine H3 receptor (hH3R) cDNA, the corresponding rat cDNA is cloned and two residues appear to be responsible for the distinct pharmacology of the H3R in the two species.
Journal ArticleDOI
Protean agonism at histamine H3 receptors in vitro and in vivo
Florence Gbahou,A. Rouleau,S. Morisset,Régis Parmentier,Sylvain Crochet,Jian-Sheng Lin,Xavier Ligneau,J. Tardivel-Lacombe,Holger Stark,Schunack Walter G,C. Robin Ganellin,J C Schwartz,Jean-Michel Arrang +12 more
TL;DR: Protean agonism demonstrates the existence of ligand-directed active states LR* different from, and competing with, constitutively active states R* of GPCRs, and defines a pharmacological entity with important therapeutic implications.
Journal ArticleDOI
Histamine H3‐receptor‐mediated [35S]GTPγ[S] binding: evidence for constitutive activity of the recombinant and native rat and human H3 receptors
A. Rouleau,Xavier Ligneau,J. Tardivel-Lacombe,S. Morisset,Florence Gbahou,J.-C. Schwartz,J.M. Arrang +6 more
TL;DR: The present study shows that the recombinant rat and human H3 receptors expressed at physiological densities display constitutive activity and suggests that constitutiveActivity of native H3Rs is one of the highest among G‐protein‐coupled receptors present in rat brain.