A
Atsushi Nakazawa
Researcher at Keio University
Publications - 38
Citations - 1988
Atsushi Nakazawa is an academic researcher from Keio University. The author has contributed to research in topics: Antigen & Cytotoxic T cell. The author has an hindex of 15, co-authored 33 publications receiving 1799 citations. Previous affiliations of Atsushi Nakazawa include Icahn School of Medicine at Mount Sinai & Mount Sinai Hospital.
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Journal ArticleDOI
IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn’s disease
Taku Kobayashi,Susumu Okamoto,Tadakazu Hisamatsu,Nobuhiko Kamada,Hiroshi Chinen,Riko Saito,Mina T. Kitazume,Atsushi Nakazawa,Akira Sugita,Kazutaka Koganei,Ken-ichi Isobe,Toshifumi Hibi +11 more
TL;DR: IL23 may play important roles in controlling the differential Th1/Th17 balance in both UC and CD, although Th17 cells may exist in both diseases.
Journal ArticleDOI
Imbalance in intestinal microflora constitution could be involved in the pathogenesis of inflammatory bowel disease.
Hiromasa Takaishi,Takahiro Matsuki,Atsushi Nakazawa,Toshihiko Takada,Shoichi Kado,Takashi Asahara,Nobuhiko Kamada,Atsushi Sakuraba,Tomoharu Yajima,Hajime Higuchi,Nagamu Inoue,Haruhiko Ogata,Yasushi Iwao,Koji Nomoto,Ryuichiro Tanaka,Toshifumi Hibi +15 more
TL;DR: Findings indicate that IBD is not caused by a specific intestinal bacterial cluster or species and that disordered intestinal microflora could be involved in the pathogenesis of IBD.
Journal ArticleDOI
CD4+NKG2D+ T Cells in Crohn’s Disease Mediate Inflammatory and Cytotoxic Responses Through MICA Interactions
Matthieu Allez,Vannary Tieng,Atsushi Nakazawa,Xavier Treton,Vincent Pacault,Nicolas Dulphy,Sophie Caillat–Zucman,Pascale Paul,Jean Marc Gornet,Corinne Douay,Sophie Ravet,Ryad Tamouza,Dominique Charron,Marc Lémann,Lloyd Mayer,Antoine Toubert +15 more
TL;DR: The role of MICA-NKG2D in the activation of a unique subset of CD4(+) T cells with inflammatory and cytotoxic properties in CD is highlighted.
Journal ArticleDOI
Defects in CD8+ Regulatory T Cells in the Lamina Propria of Patients With Inflammatory Bowel Disease
TL;DR: It is demonstrated that CD8+ T cells with regulatory activity are present in the LP of normal healthy individuals, but not in patients with IBD, suggesting that these cells might play an active role in mucosal tolerance.
Journal ArticleDOI
The expression and function of costimulatory molecules B7H and B7-H1 on colonic epithelial cells☆
Atsushi Nakazawa,Iris Dotan,Jens Brimnes,Matthieu Allez,Ling Shao,Fumihiko Tsushima,Miyuki Azuma,Lloyd Mayer +7 more
TL;DR: Data suggest that the B7h-ICOS costimulatory pathway may be important in IEC:T-cell interactions.