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Atsuya Akabane
Researcher at Tohoku University
Publications - 14
Citations - 606
Atsuya Akabane is an academic researcher from Tohoku University. The author has contributed to research in topics: Radiosurgery & Transgene. The author has an hindex of 12, co-authored 14 publications receiving 575 citations.
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Journal ArticleDOI
Regulatory Role of CD38 (ADP-ribosyl Cyclase/Cyclic ADP-ribose Hydrolase) in Insulin Secretion by Glucose in Pancreatic βCells ENHANCED INSULIN SECRETION IN CD38-EXPRESSING TRANSGENIC MICE
Ichiro Kato,Shin Takasawa,Atsuya Akabane,Osamu Tanaka,Hiroshi Abe,Toshinari Takamura,Yu Suzuki,Koji Nata,Hideto Yonekura,Takashi Yoshimoto,Hiroshi Okamoto +10 more
TL;DR: The present study provides the first evidence that CD38 has a regulatory role in insulin secretion by glucose in beta cells, suggesting that the Ca2+ release from intracellular cADPR-sensitive Ca2-sensitive stores as well as theCa2+ influx from extracellular sources play important roles in insulin gland secretion.
Journal Article
Serial follow-up MR imaging after gamma knife radiosurgery for vestibular schwannoma.
Hiroyuki Nakamura,Hidefumi Jokura,Kou Takahashi,Nagatoshi Boku,Atsuya Akabane,Takashi Yoshimoto +5 more
TL;DR: Dynamic changes in vestibular schwannoma are seen on serial follow-up MR studies obtained after gamma knife radiosurgery, and an increase in tumor size up to 2 years after radiosur surgery is likely to be followed by regression.
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Induction of brain-derived neurotrophic factor (BDNF) and the receptor trk B mRNA following middle cerebral artery occlusion in rat
Shouichi Arai,Hiroyuki Kinouchi,Atsuya Akabane,Yuji Owada,Hideyuki Kamii,Makoto Kawase,Takashi Yoshimoto +6 more
TL;DR: In situ hybridization studies showed that BDNF and trk B mRNAs were induced in a widespread region of the ipsilateral cortex outside the infarct at 4 h following MCA occlusion, and were also induced in the bilateral hippocampi which are remote from the ischemic MCA region.
Journal ArticleDOI
Value of constructive interference in steady-state three-dimensional, Fourier transformation magnetic resonance imaging for the neuroendoscopic treatment of hydrocephalus and intracranial cysts.
TL;DR: CISS imaging provides excellent cerebrospinal fluid/brain tissue contrast, allowing detailed study of the anatomic features of the ventricular system and cystic lesions, and is valuable for both preoperative decision-making and postoperative evaluation.
Journal ArticleDOI
Transgenic mice overexpressing human vasoactive intestinal peptide (VIP) gene in pancreatic beta cells. Evidence for improved glucose tolerance and enhanced insulin secretion by VIP and PHM-27 in vivo.
Ichiro Kato,Yoichi Suzuki,Atsuya Akabane,Hideto Yonekura,O. Tanaka,Hiroshi Kondo,Shin Takasawa,Takashi Yoshimoto,Hiroshi Okamoto +8 more
TL;DR: The results indicate that VIP and PHM-27 produced from the transgenic beta cells efficiently enhance glucose-induced insulin secretion from beta cells by an autocrine mechanism, and suggest that genetic manipulation of islet Beta cells by the human VIP/PHM- 27 gene or delivery of VIP to beta cells may ultimately provide a valuable approach to enhancing insulin secretion in clinical diabetes.