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Audrey H. Effenberger
Researcher at Harvard University
Publications - 4
Citations - 113
Audrey H. Effenberger is an academic researcher from Harvard University. The author has contributed to research in topics: Mantella & Climbing mantella. The author has an hindex of 2, co-authored 2 publications receiving 12 citations.
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Journal ArticleDOI
APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes
Joel W. Blanchard,Leyla Anne Akay,Jose Davila-Velderrain,Djuna von Maydell,Hansruedi Mathys,Shawn M. Davidson,Audrey H. Effenberger,Chih-Yu Chen,Kristal M. Maner-Smith,Ihab Hajjar,Eric A. Ortlund,Michael Bula,Emre Agbas,Ayesha P. Ng,Xueqiao Jiang,Martin Kahn,C Blanco-Duque,Nicolas Lavoie,Liwang Liu,Ricardo Reyes,Yuan-Ta Lin,Tak Ko,Lea R'Bibo,William T. Ralvenius,David A. Bennett,Hugh P. Cam,Manolis Kellis,Li-Huei Tsai +27 more
TL;DR: In this article , a single-cell transcriptomics profiling of post-mortem human brains from APOE4 carriers compared with non-carriers was performed to gain more comprehensive insights into the impact of APOE-4 on the human brain.
Posted ContentDOI
Lipid Accumulation Induced by APOE4 Impairs Microglial Surveillance of Neuronal-Network Activity
Matheus B. Victor,Noelle Leary,Xochitl Luna,Hiruy S. Meharena,P. Lorenzo Bozzelli,George Azaz Samaan,Mitchell H. Murdock,Djuna von Maydell,Audrey H. Effenberger,Oyku Cerit,Hsin-Lan Wen,Liwang Liu,Gwyneth Margaret Welch,Maeve Bonner,Li-Huei Tsai +14 more
TL;DR: The results reveal that APOE4 induces a distinct metabolic program in microglia that is marked by the accumulation of intracellular neutral lipid stores through impaired lipid catabolism, suggesting that neurological diseases that exhibit abnormal neuronal network-level disturbances may in part be triggered by impairment in lipid homeostasis in non-neuronal cells.
Journal ArticleDOI
Seasonal changes in diet and chemical defense in the Climbing Mantella frog (Mantella laevigata)
Nora A. Moskowitz,Alexandre B. Roland,Eva K. Fischer,Ndimbintsoa Ranaivorazo,Charles Vidoudez,Marianne T. Aguilar,Sophia Caldera,Jacqueline Chea,Miruna G. Cristus,Jett Crowdis,Bluyé DeMessie,Caroline R. DesJardins-Park,Audrey H. Effenberger,Francisco J. Flores,Michael Giles,Emma Y. He,Nike S. Izmaylov,ChangWon C. Lee,Nicholas A. Pagel,Krystal K Phu,Leah U. Rosen,Danielle A. Seda,Yong Shen,Santiago Vargas,Andrew W. Murray,Eden Abebe,Sunia A. Trauger,David A. Donoso,Miguel Vences,Lauren A. O’Connell,Lauren A. O’Connell +30 more
TL;DR: This work found that frog diet differed between the wet and dry seasons, where frogs had a more diverse diet in the wet season and consumed a higher percentage of ants in the dry season, suggesting that alkaloid profiles are relatively robust against short-term environmental perturbations.
Posted ContentDOI
Seasonal Changes in Diet and Toxicity in the Climbing Mantella Frog (Mantella Laevigata)
Nora A. Moskowitz,Alexandre B. Roland,Eva K. Fischer,Ndimbintsoa Ranaivorazo,Charles Vidoudez,Marianne T. Aguilar,Sophia Caldera,Jacqueline Chea,Miruna G. Cristus,Jett Crowdis,Bluyé DeMessie,Caroline R. DesJardins-Park,Audrey H. Effenberger,Francisco J. Flores,Michael Giles,Emma Y. He,Nike S. Izmaylov,ChangWon C. Lee,Nicholas A. Pagel,Krystal K Phu,Leah U. Rosen,Danielle A. Seda,Yong Shen,Santiago Vargas,Andrew W. Murray,Eden Abebe,Sunia A. Trauger,David A. Donoso,Miguel Vences,Lauren A. O’Connell +29 more
TL;DR: Investigating how seasonal environmental variation influences poison frog toxin profiles through changes in the diet of the Climbing Mantella (Mantella laevigata) suggests that toxin profiles are relatively robust against short-term environmental perturbations.