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Xueqiao Jiang
Researcher at Picower Institute for Learning and Memory
Publications - 10
Citations - 1547
Xueqiao Jiang is an academic researcher from Picower Institute for Learning and Memory. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 3, co-authored 5 publications receiving 704 citations. Previous affiliations of Xueqiao Jiang include Massachusetts Institute of Technology.
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Journal ArticleDOI
Single-cell transcriptomic analysis of Alzheimer’s disease
Hansruedi Mathys,Hansruedi Mathys,Jose Davila-Velderrain,Jose Davila-Velderrain,Zhuyu Peng,Zhuyu Peng,Fan Gao,Fan Gao,Shahin Mohammadi,Shahin Mohammadi,Jennie Z. Young,Jennie Z. Young,Madhvi Menon,Madhvi Menon,Liang He,Liang He,Fatema Abdurrob,Fatema Abdurrob,Xueqiao Jiang,Xueqiao Jiang,Anthony J Martorell,Anthony J Martorell,Richard M. Ransohoff,Brian P. Hafler,David A. Bennett,Manolis Kellis,Manolis Kellis,Li-Huei Tsai,Li-Huei Tsai,Li-Huei Tsai +29 more
TL;DR: Single-cell transcriptomics from 48 individuals with varying degrees of Alzheimer's disease pathology demonstrates that gene-expression changes in Alzheimer’s disease are both cell-type specific and shared, and that transcriptional responses show sexual dimorphism.
Journal ArticleDOI
Single-cell dissection of the human brain vasculature
Francisco J. Garcia,Na Sun,Hyeseung Janice Lee,Brianna Godlewski,Hansruedi Mathys,Kyriaki Galani,Blake Zhou,Xueqiao Jiang,Ayesha P. Ng,Julio C. Mantero,Li-Huei Tsai,David A. Bennett,Mustafa Sahin,Manolis Kellis,Myriam Heiman +14 more
TL;DR: This article performed single-cell characterization of the human cerebrovasculature using both ex vivo fresh tissue experimental enrichment and post mortem in silico sorting of human cortical tissue samples.
Journal ArticleDOI
APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes
Joel W. Blanchard,Leyla Anne Akay,Jose Davila-Velderrain,Djuna von Maydell,Hansruedi Mathys,Shawn M. Davidson,Audrey H. Effenberger,Chih-Yu Chen,Kristal M. Maner-Smith,Ihab Hajjar,Eric A. Ortlund,Michael Bula,Emre Agbas,Ayesha P. Ng,Xueqiao Jiang,Martin Kahn,C Blanco-Duque,Nicolas Lavoie,Liwang Liu,Ricardo Reyes,Yuan-Ta Lin,Tak Ko,Lea R'Bibo,William T. Ralvenius,David A. Bennett,Hugh P. Cam,Manolis Kellis,Li-Huei Tsai +27 more
TL;DR: In this article , a single-cell transcriptomics profiling of post-mortem human brains from APOE4 carriers compared with non-carriers was performed to gain more comprehensive insights into the impact of APOE-4 on the human brain.
Journal ArticleDOI
Author Correction: Single-cell transcriptomic analysis of Alzheimer's disease.
Hansruedi Mathys,Jose Davila-Velderrain,Zhuyu Peng,Zhuyu Peng,Fan Gao,Fan Gao,Shahin Mohammadi,Shahin Mohammadi,Jennie Z. Young,Jennie Z. Young,Madhvi Menon,Liang He,Liang He,Fatema Abdurrob,Fatema Abdurrob,Xueqiao Jiang,Xueqiao Jiang,Anthony J Martorell,Anthony J Martorell,Richard M. Ransohoff,Brian P. Hafler,David A. Bennett,Manolis Kellis,Manolis Kellis,Li-Huei Tsai,Li-Huei Tsai,Li-Huei Tsai +26 more
TL;DR: In this Article, the Acknowledgements section should have included that the work was supported in part by the Cure Alzheimer’s Fund (CAF), and the final NIH grant acknowledged should have been ‘U01MH119509’ instead of ‘RF1AG054012’.
Journal ArticleDOI
AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation.
Faten A. Sayed,Lay Kodama,Li Fan,Gillian K. Carling,Joe C. Udeochu,David Le,Qingyun Li,Lu Zhou,Man Ying Wong,Rose Horowitz,Pearly Ye,Hansruedi Mathys,Minghui Wang,Xiang Niu,Linas Mazutis,Xueqiao Jiang,Xueting Wang,Fuying Gao,Matthew Brendel,Maria Telpoukhovskaia,Tara E. Tracy,Georgia R. Frost,Yungui Zhou,Yaqiao Li,Yue Qiu,Zuolin Cheng,Guoqiang Yu,John Hardy,Giovanni Coppola,Fei Wang,Michael DeTure,Bin Zhang,Lei Xie,John Q. Trajnowski,Virginia M.-Y. Lee,Shiaoching Gong,Subhash C. Sinha,Dennis W. Dickson,Wenjie Luo,Li Gan +39 more
TL;DR: The hemizygous R47H variant of triggering receptor expressed on myeloid cells 2 (TREM2), a microglia-specific gene in the brain, increases risk for late-onset Alzheimer's disease (AD) as mentioned in this paper.