D
Djuna von Maydell
Researcher at Harvard University
Publications - 6
Citations - 182
Djuna von Maydell is an academic researcher from Harvard University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 2, co-authored 3 publications receiving 40 citations.
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Journal ArticleDOI
Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer's disease.
Sang Su Kwak,Kevin J. Washicosky,Emma Brand,Djuna von Maydell,Jenna Aronson,Jenna Aronson,Susan Kim,Diane E. Capen,Murat Cetinbas,Ruslan I. Sadreyev,Shen Ning,Shen Ning,Enjana Bylykbashi,Weiming Xia,Weiming Xia,Steven L. Wagner,Se Hoon Choi,Rudolph E. Tanzi,Doo Yeon Kim +18 more
TL;DR: It is shown that it is the increased ratio of amyloid-β42 and 40 isoforms drives tau pathology in 3D human neural cell culture models of the disease, emphasizing the importance of reducing the Aβ42/40 ratio in AD therapy.
Journal ArticleDOI
APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes
Joel W. Blanchard,Leyla Anne Akay,Jose Davila-Velderrain,Djuna von Maydell,Hansruedi Mathys,Shawn M. Davidson,Audrey H. Effenberger,Chih-Yu Chen,Kristal M. Maner-Smith,Ihab Hajjar,Eric A. Ortlund,Michael Bula,Emre Agbas,Ayesha P. Ng,Xueqiao Jiang,Martin Kahn,C Blanco-Duque,Nicolas Lavoie,Liwang Liu,Ricardo Reyes,Yuan-Ta Lin,Tak Ko,Lea R'Bibo,William T. Ralvenius,David A. Bennett,Hugh P. Cam,Manolis Kellis,Li-Huei Tsai +27 more
TL;DR: In this article , a single-cell transcriptomics profiling of post-mortem human brains from APOE4 carriers compared with non-carriers was performed to gain more comprehensive insights into the impact of APOE-4 on the human brain.
Posted ContentDOI
Lipid Accumulation Induced by APOE4 Impairs Microglial Surveillance of Neuronal-Network Activity
Matheus B. Victor,Noelle Leary,Xochitl Luna,Hiruy S. Meharena,P. Lorenzo Bozzelli,George Azaz Samaan,Mitchell H. Murdock,Djuna von Maydell,Audrey H. Effenberger,Oyku Cerit,Hsin-Lan Wen,Liwang Liu,Gwyneth Margaret Welch,Maeve Bonner,Li-Huei Tsai +14 more
TL;DR: The results reveal that APOE4 induces a distinct metabolic program in microglia that is marked by the accumulation of intracellular neutral lipid stores through impaired lipid catabolism, suggesting that neurological diseases that exhibit abnormal neuronal network-level disturbances may in part be triggered by impairment in lipid homeostasis in non-neuronal cells.
Journal ArticleDOI
The interplay between microglial states and major risk factors in Alzheimer’s disease through the eyes of single-cell RNA-sequencing: beyond black and white
Djuna von Maydell,Mehdi Jorfi +1 more
TL;DR: Insight is provided into the cellular mechanisms of AD and the potential of novel cell-based therapies for AD is underlined, suggesting that shifts along the trajectory might play a causal role in AD pathogenesis.
Book ChapterDOI
A Synergistic Engineering Approach to Build Human Brain Spheroids.
Djuna von Maydell,Mehdi Jorfi +1 more
TL;DR: In this article, a method was proposed to generate large-scale arrays of homogeneously sized 3D brain spheroids derived from human-induced pluripotent stem cells (hiPSCs) or immortalized neural progenitor cells to recapitulate Alzheimer's disease (AD) pathology in vitro.